• Publications
  • Influence
Singlet nuclear magnetic resonance of nearly-equivalent spins.
  • M. Tayler, M. Levitt
  • Chemistry, Medicine
    Physical chemistry chemical physics : PCCP
  • 16 March 2011
TLDR
Experiments on the terminal glycine resonances of the tripeptide alanylglycylglycine in aqueous solution are demonstrated, showing that the nuclear singlet order of this system is long-lived even when no resonant locking field is applied.
Recycling and imaging of nuclear singlet hyperpolarization.
TLDR
A combination of long-lived singlet states, molecular design, magnetic field cycling, and specific radiofrequency pulse sequences allows repeated observation of the same batch of polarized nuclei over a period of 30 min and more.
Determination of molecular torsion angles using nuclear singlet relaxation.
TLDR
The exponential relaxation time constant, T(S), of a nuclear singlet state is influenced by the proximity of neighboring NMR-active nuclei and provides a new route for determining torsional angles plus other molecular structural details in the isotropic solution phase.
Direct enhancement of nuclear singlet order by dynamic nuclear polarization.
Hyperpolarized singlet order is available immediately after dissolution DNP, avoiding need for additional preparation steps. We demonstrate this procedure on a sample of [1,2-(13)C(2)]pyruvic acid.
Invited Review Article: Instrumentation for nuclear magnetic resonance in zero and ultralow magnetic field.
We review experimental techniques in our laboratory for nuclear magnetic resonance (NMR) in zero and ultralow magnetic field (below 0.1 μT) where detection is based on a low-cost, non-cryogenic,
Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
TLDR
It is shown that in human blood and in a mouse in vivo at millitesla fields the 13C singlet lifetime of [1,2‐13C2]pyruvate was significantly longer than the13C T1, although it was shorter than the T1 at field strengths of several tesla.
Paramagnetic relaxation of nuclear singlet states.
  • M. Tayler, M. Levitt
  • Chemistry, Medicine
    Physical chemistry chemical physics : PCCP
  • 3 May 2011
TLDR
A linear correlation is found between the singlet relaxation rate constant T and the longitudinal relaxation rate constants T and typically, singlet states are between two to three times less sensitive to paramagnetic relaxation than conventional nuclear magnetization.
Unraveling the spectroscopy of coupled intramolecular tunneling modes: a study of double proton transfer in the formic-acetic acid complex.
TLDR
The rotational spectrum of the hetero dimer comprising doubly hydrogen-bonded formic acid and acetic acid has been recorded between 4 and 18 GHz using a pulsed-nozzle Fourier transform microwave spectrometer and a full assignment of the spectrum is presented.
Accessing long-lived nuclear spin order by isotope-induced symmetry breaking.
  • M. Tayler, M. Levitt
  • Chemistry, Medicine
    Journal of the American Chemical Society
  • 5 February 2013
TLDR
Access to (13)C(2) singlet states in a symmetrical oxalate molecule is shown by substituting one or more (16)O nuclei by the stable nonmagnetic isotope (18)O.
Hyperpolarized singlet NMR on a small animal imaging system
TLDR
The demonstration of robust singlet‐to‐magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.
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