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Prospective epidemiological study of thorotrast-exposed patients in Portugal.
A statistical analysis of the data has shown that the number of observed deaths from malignancies in general—and particularly from primary liver, bone, bronchus, and larynx tumors, and from leukemias—and from liver cirrhosis in the Thorotrast cases is significantly higher than expected. Expand
Thorium dioxide effects in man. Epidemiological, clinical, and pathological studies (experience in Portugal).
The authors conclude that Thorotrast must have been the cause of such pathological consequences, probably through its radioactivity, and therefore should not be used in human beings. Expand
Malignancies in Portuguese thorotrast patients.
Of 2434 individuals who received Thorotrast in Portugal, mostly from 1930 to 1950, 1237 (or 51%) have been traced and followed up and 931 of these had died, significantly above the corresponding expected number in the general Portuguese population. Expand
Thorium dioxide and the liver: up-dated clinical and biochemical findings.
A correlation has been found between the length of time elapsed after injection and the incidence of abnormal biochemical findings. Expand
An unusual evolution in a patient injected with throium dioxide.
A woman injected with thorium dioxide in 1942, who 35 years later developed clinical, laboratory, scintigraphic, and echographic data very suggestive of liver tumor, as has been described in patients injected withThorium dioxide, recovers subjectively and objectively after symptomatic therapy. Expand
Leukaemia, malignancies and other late effects following administration of Thorotrast
The results of this investigation suggest that local human “cancerisation” can occur and the radiation-leukaemia “risk” estimates which can be derived are important contributions to the sum of available human radiation risk data on leukaemia. Expand
Thorium dioxide and the liver--scintigraphic aspects.
Twenty-four patients followed up by the Portuguese Thorotrast Study Group had liver radioisotopic visualization. A high rate of scans typical of advanced malignancy was found and the authors feelExpand