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Sirtuin activators mimic caloric restriction and delay ageing in metazoans
TLDR
It is shown that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity, indicating that STacs slow metazoan ageing by mechanisms that may be related to caloric restriction. Expand
A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
TLDR
It is concluded that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue. Expand
The Endocrine Regulation of Aging by Insulin-like Signals
TLDR
Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
TLDR
It is demonstrated here that dFOXO regulates D. melanogaster ageing when activated in the adult pericerebral fat body and reduces expression of the Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body. Expand
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
TLDR
Drosophila sNPF and the evolutionarily conserved mammalian NPY seem to regulate ERK-mediated insulin expression and thus to systemically modulate growth, metabolism and lifespan. Expand
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
TLDR
It is argued that studying “hormonal pleiotropy” offers intriguing insights into phenotypic integration and the mechanisms underlying life history evolution, and illustrated the role of JH as a key mediator of life history trade‐offs. Expand
Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
TLDR
It is shown that the insulin‐regulated transcription factor dFOXO positively modulates dilp6 mRNA in adult fat body, appearing to bridge d FOXO, adipose tissue and brain endocrine function to regulate Drosophila longevity. Expand
Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms
TLDR
This work proposes neuroendocrine control of reproductive diapause in D. melanogaster that includes phenotypic plasticity for rates of senescence, and suggests slow aging during the diAPause period may involve elevated somatic stress resistance as well as reallocation of resources to somatic maintenance. Expand
Drosophila germ-line modulation of insulin signaling and lifespan
TLDR
It is reported that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling, suggesting that signals from the gonad regulate lifespan andmodulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved. Expand
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