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Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema
Background: It has previously been shown that smokers with computed tomographic (CT) evidence of subclinical emphysema have signs of neutrophil activation, despite having no appreciable increase in… Expand
Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma.
BACKGROUND Ionizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although… Expand
STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
- S. Kohsaka, L. Wang, +7 authors S. Tanaka
- Biology, Medicine
- Molecular Cancer Therapeutics
- 24 April 2012
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with a poor prognosis. Current standard treatment includes chemotherapy with the DNA-alkylating agent temozolomide concomitant… Expand
Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase
Shp2 is a positive regulator for Erk activation downstream of receptor tyrosine kinases for growth factors. It has been controversial how Shp2 induces Erk activation. We here demonstrate that EphA2… Expand
Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema.
- T. Betsuyaku, M. Nishimura, +4 authors Y. Kawakami
- American journal of respiratory and critical care…
- 1 June 1999
Evidence for the contribution of neutrophils to the pathogenesis of pulmonary emphysema is not convincing. We evaluated neutrophil involvement in subclinical pulmonary emphysema by measuring human… Expand
Cysteine proteinases and cystatin C in bronchoalveolar lavage fluid from subjects with subclinical emphysema.
- K. Takeyabu, T. Betsuyaku, +4 authors Y. Kawakami
- The European respiratory journal
- 1 November 1998
This study examined the role of cysteine proteinases and their inhibitor in the development of emphysema in comparison with neutrophil elastase (NE) complexed with alpha1-protease inhibitor… Expand
Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. However, ovarian cancers often acquire… Expand
Promoter hypomethylation regulates CD133 expression in human gliomas
Brain tumor-initiating cells (BTICs) have been enriched using antibodies against the cell surface protein CD133; however, the biological relevance and the regulatory mechanism of CD133 expression in… Expand
Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4.
- L. Wang, K. Tabu, +6 authors S. Tanaka
- Medicine, Biology
- Biochemical and biophysical research…
- 3 November 2007
Signaling adaptor protein Crk has been shown to be involved in pathogenesis of human cancers including brain tumor where Crk was reported to be overexpressed. In this study, we addressed whether Crk… Expand
A case of atypical teratoid/rhabdoid tumor in an adult, with long survival
- Kenta Takahashi, H. Nishihara, +9 authors S. Tanaka
- Biology, Medicine
- Brain Tumor Pathology
- 1 February 2011
Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant tumor that mostly occurs in early childhood and has poor prognosis despite aggressive therapy. Adult cases are rare and, as far as we are… Expand