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Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure.
TLDR
It is concluded that early long-term Ena therapy attenuates cardiomyocyte apoptosis in dogs with moderate HF, and may be one mechanism by which ACE inhibitors preserve global LV function in HF. Expand
Effects of Dopamine β-Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure
TLDR
A randomized, blinded, placebo-controlled investigation of the long-term effects of therapy with the DBH inhibitor nepicastat (NCT) on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Expand
Effects of long-term therapy with bosentan on the progression of left ventricular dysfunction and remodeling in dogs with heart failure.
TLDR
In dogs with moderate HF, long-term therapy with bosentan prevents the progression of LV dysfunction and attenuates LV chamber remodeling and the findings support the use of mixed endothelin-1 receptor antagonists as adjuncts to the long- term treatment of HF. Expand
Effects of AT1-receptor blockade on progression of left ventricular dysfunction in dogs with heart failure.
TLDR
It is concluded that, for dogs with moderate HF, early long-term therapy with the AT1-receptor blocker valsartan decreases preload and afterload but has only limited benefits in attenuating the progression of LV dysfunction and chamber remodeling. Expand
Hemodynamic Effects of a Novel Sodium Channel Activator in Dogs With Chronic Heart Failure
TLDR
It is concluded that in dogs with HF, intravenous LY improves LV function to the same extent as DOB without increasing HR or evoking ventricular arrhythmias and the combination of LY with digoxin elicits a safe positive inotropic response. Expand
Effects of Chronic Neutral Endopeptidase Inhibition on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs with Moderate Heart Failure
TLDR
Early, long-term NEP inhibition with ecadotril prevents the progression of LV dysfunction and attenuates progressive LV remodeling in dogs with moderate heart failure. Expand
Prediction of functional recovery of the left ventricle after coronary revascularization in patients with prior anterior myocardial infarction: a myocardial integrated backscatter study.
TLDR
IBS is valuable for predicting LV functional recovery after coronary revascularization in patients with LV dysfunction caused by a remote anterior MI, and a large-scale study is needed to establish these data. Expand
Effects of Dopamineb-Hydroxylase Inhibition With Nepicastat on the Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Chronic Heart Failure
Background—Inhibition of dopamineb-hydroxylase (DBH) results in a decrease in norepinephrine synthesis. The present study was a randomized, blinded, placebo-controlled investigation of the long-termExpand
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