• Publications
  • Influence
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM, symptoms that resemble those of patients with X-linked hyper-IgM syndrome andExpand
  • 382
  • 29
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a totalExpand
  • 277
  • 8
Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.
BACKGROUND NLR family, pyrin domain containing 3 (NLRP3), controls the activity of inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines IL-1beta and IL-18.Expand
  • 130
  • 8
Diagnosis and management of NSAID‐Exacerbated Respiratory Disease (N‐ERD)—a EAACI position paper
NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasalExpand
  • 100
  • 7
  • PDF
A clinical study of idiopathic eosinophilic pneumonia.
To better characterize idiopathic eosinophilic pneumonia (IEP), we studied the clinical and laboratory features of 27 patients. Patients with IEP could be divided into those with chronic eosinophilicExpand
  • 116
  • 5
Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma.
BACKGROUND The A to C transversion in the promoter region of the gene encoding leukotriene C4 synthase (LTC4S) is proposed to be associated with the development of aspirin-induced asthma (AIA). Expand
  • 133
  • 5
Possible involvement of mast‐cell activation in aspirin provocation of aspirin‐induced asthma
Background: Although there is increasing evidence of the importance of cysteinyl leukotrienes (LT) as mediators of aspirin‐induced bronchoconstriction in aspirin‐sensitive asthma, the cellular originExpand
  • 75
  • 5
Sensitization to fungal allergens: Resolved and unresolved issues.
Exposure and sensitization to fungal allergens can promote the development and worsening of allergic diseases. Although numerous species of fungi have been associated with allergic diseases in theExpand
  • 95
  • 5
  • PDF
Urinary 3‐bromotyrosine and 3‐chlorotyrosine concentrations in asthmatic patients: lack of increase in 3‐bromotyrosine concentration in urine and plasma proteins in aspirin‐induced asthma after
Background Eosinophil peroxidase and myeloperoxidase halogenate tyrosine residues in plasma proteins and generate 3‐bromotyrosine (BY) and 3‐chlorotyrosine (CY), respectively.
  • 55
  • 4
Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis
Background Anaphylaxis is a life‐threatening syndrome resulting from the sudden release of mast cell‐ and basophil‐derived mediators into the circulation. However, pathological evidence of theExpand
  • 87
  • 4