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Estradiol-17beta as an antioxidant: some distinct features when compared with common fat-soluble antioxidants.
It is shown that estradiol is as effective an antioxidant as alpha-tocopherol in terms of fatty acid peroxidation but is far more effective than beta-caroteneIn terms of cholesterol oxidation, Estradiol was far moreeffective than alpha-ocopherol or beta- carotene in inhibiting oxysterol formation. Expand
Superior and distinct antioxidant effects of selected estrogen metabolites on lipid peroxidation.
Although all estrogens significantly reduced lipid peroxidation, 4-hydroxyestrone was far more potent than either equilin or 17alpha-dihydroequilin in inhibiting TBARS formation in lipoproteins induced by Cu2+. Expand
Association of estrogens with human plasma lipoproteins: studies using estradiol-17beta and its hydrophobic derivative.
Although the association of E 2 with HDL under normal conditions may be small, it increases significantly with higher estrogen concentrations of E2; the hydrophobic ester of E1 shows increased binding to VLDL and LDL; and this approach may be useful in manipulating the delivery of selected E2 derivatives to cells. Expand
Estrogens protect against hydrogen peroxide and arachidonic acid induced DNA damage.
These studies suggest that estrogens through this protective effect on DNA damage might contribute to cardioprotection. Expand
Cholest-3,5-dien-7-one formation in peroxidized human plasma as an indicator of lipoprotein cholesterol peroxidation potential.
Under the influence of Cu2+ ions, the major product of lipoprotein cholesterol peroxidation (isolated after saponification) was cholest-3-5-dien-7-one (CSD), and this compound lends itself for measurement by alternative methods. Expand
Induction of Methionine Adenosyltransferase in Rat Liver by Corticosteroids∗
The results suggest that the changes in the hepatic levels of methionine adenosyltransferase brought about by glucocorticoids represent enzyme synthesis de novo probably involving enhanced DNA-directed RNA production. Expand