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Mitochondrial genome variation in eastern Asia and the peopling of Japan.
- M. Tanaka, V. Cabrera, +25 authors Hidetoshi Shimodaira
- Biology, Medicine
- Genome research
- 1 October 2004
To construct an East Asia mitochondrial DNA (mtDNA) phylogeny, we sequenced the complete mitochondrial genomes of 672 Japanese individuals (http://www.giib.or.jp/mtsnp/index_e.html). This allowed us… Expand
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
BACKGROUND: Although epidemiologic studies have suggested that several genetic variants increase the risk of myocardial infarction, large-scale association studies that examine many polymorphisms… Expand
MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES
The human mitochondrial genome is very small and economically packed; the expression of the whole genome is essential for the maintenance of mitochondrial bioenergetic function. Mutation occurs at a… Expand
Trehalose extends longevity in the nematode Caenorhabditis elegans
Trehalose is a disaccharide of glucose found in diverse organisms and is suggested to act as a stress protectant against heat, cold, desiccation, anoxia, and oxidation. Here, we demonstrate that… Expand
Mitochondrial genotype associated with longevity
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be… Expand
Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan
We report results from the analysis of complete mitochondrial DNA (mtDNA) sequences from 112 Japanese semi-supercentenarians (aged above 105 years) combined with previously published data from 96… Expand
Mitochondrial DNA analysis of Hokkaido Jomon skeletons: remnants of archaic maternal lineages at the southwestern edge of former Beringia.
- N. Adachi, K. Shinoda, +5 authors M. Tanaka
- Geography, Medicine
- American journal of physical anthropology
- 1 November 2011
To clarify the colonizing process of East/Northeast Asia as well as the peopling of the Americas, identifying the genetic characteristics of Paleolithic Siberians is indispensable. However, no… Expand
Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians.
- N. Fuku, K. Park, +10 authors M. Tanaka
- Medicine, Biology
- American journal of human genetics
- 1 March 2007
Because mitochondria play pivotal roles in both insulin secretion from the pancreatic beta cells and insulin resistance of skeletal muscles, we performed a large-scale association study to identify… Expand
Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans
In Caenorhabditis elegans, the downregulation of insulin-like signaling induces lifespan extension (Age) and the constitutive formation of dauer larvae (Daf-c). This also causes resistance to… Expand