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FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium
We disrupted the FOG-2 gene in mice to define its requirement in vivo. FOG-2(-/-) embryos die at midgestation with a cardiac defect characterized by a thin ventricular myocardium, commonExpand
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Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.
Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiacExpand
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Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percentExpand
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ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES
Acyl glucuronidation is an important metabolic pathway for fluoroquinolone antibiotics. However, it is unclear which human UDP-glucuronosyltransferase (UGT) enzymes are involved in theExpand
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Consumers’ willingness to pay for alternative fuel vehicles: A comparative discrete choice analysis between the US and Japan
This paper conducts a comparative discrete choice analysis to estimate consumers’ willingness to pay (WTP) for electric vehicles (EVs) and plug-in hybrid electric vehicles (PHEVs) on the basis of theExpand
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NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain
The selectivity of N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ehthylamine monohydrochloride (NE-100) for σ1 and σ2 binding sites was studied by means of binding of [3H](+)-pentazocine andExpand
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An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
We have compared plasma redox status of coenzyme Q-10 in 20 sporadic amyotrophic lateral sclerosis (sALS) patients with those in 20 healthy age/sex-matched controls. A significant increase in theExpand
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Twenty-two percent efficiency HIT solar cell
Abstract We have achieved the world's highest solar cell conversion efficiency of 22.3% (Voc: 0.725 V, Isc: 3.909 A, FF: 0.791, total area: 100.5 cm2, confirmed by AIST) by using a heterojunctionExpand
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ABCA2 Deficiency Results in Abnormal Sphingolipid Metabolism in Mouse Brain*
ABCA2, a member of the ATP-binding cassette (ABC) transporter family, is localized mainly to late endosome/lysosomes of oligodendrocytes in brain, but the physiological role and function of ABCA2 areExpand
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Coexistent emphysema delays the decrease of vital capacity in idiopathic pulmonary fibrosis.
Although previous authors have reported single data point, yearly changes in respiratory function have not been examined in combined pulmonary fibrosis and emphysema (CPFE). To quantify the annualExpand
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