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Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus
TLDR
The number of viable mutant cells decreased at non-permissive temperature, suggesting that inactivation of DnaE and PolC has a bactericidal effect and that these enzymes are potential targets of antibiotics. Expand
Structural and functional analysis of monomorphic determinants recognized by monoclonal antibodies reacting with the HLA class I alpha 3 domain.
TLDR
Results indicate that mAb TP25.99 has unique specificity and functional characteristics and represents a valuable probe to characterize the role of the HLA class I alpha 3 domain in immunologic phenomena. Expand
The allorecognition of H-2Kb-specific CD4-CD8- T cell hybridomas is influenced by the substitution at residue 256 of MHC class I molecules.
TLDR
Results of this study demonstrated that polymorphism of the alpha 3 domain is indeed involved in the formation of allodeterminants recognized by TCR. Expand
Beta-chain broadens range of CD8 recognition for MHC class I molecule.
TLDR
The results suggest that the beta-chain allows the CD8 alpha beta heterodimer to recognize the chimeric H-2Kb Ag, and a model for the role of the Beta-chain is presented. Expand
Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth.
TLDR
Results suggested that BM microenvironment might play important roles in the pathogenesis of MM and RA. Expand
Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site.
TLDR
This study demonstrated that HTLV-1-derived transactivator protein, p40tax, could stimulate endogenous IL-6 gene expression and identified the presence of two nuclear factor complexes that bound to the IL- 6 kappa B site. Expand
Functional expression of HLA-C blank antigens on human blood lymphocytes.
TLDR
It is demonstrated that these Ag on normal PBL are able to induce specific CTL and that the capacity of these Ag to induce allogeneic CTL is almost identical to that of HLA-B Ag, indicating that they may function as alloantigens in vivo and play a significant role in the rejection of organ grafts and in the graft-versus-host reaction in bone marrow transplantation. Expand
Different effects of substitutions at residues 224 and 228 of MHC class I on the recognition of CD8.
TLDR
It is demonstrated that each substitution at residues 224 and 228 affects recognition of CD8-dependent mouse CTL clones, and that IL-2-producing H-2Kb-specific T cell hybridoma transfected with mouse CD8 alpha was abrogated by substitution at residue 224 but not by that at residue 228. Expand
The structure ofHLA-B35 suggests that it is derived fromHLA-Bw58 by two genetic mechanisms
TLDR
Data suggest that HLA-B35 has evolved fromHLA- Bw58 in two steps; an in vivo replacement of the α1 domain withHLA's Bw4/Bw6-associated amino acids and genetic exchange with one of theHLA the Bw6 genes. Expand
Antigen recognition by the T cell receptor is enhanced by CD8 α-chain binding to the α3 domain of MHC class I molecules, not by signaling via the cytoplasmic domain of CD8α
TLDR
The data suggest that the mouse CD8 alpha homodimer does not bind to the alpha 3 domain of HLA class I molecules and that CD8alpha acts as a co-receptor with the TCR by binding the same MHC molecule for alloantigen recognition. Expand
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