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TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
Purpose: TGF-β promotes tumor invasion and metastasis by inducing an epithelial–mesenchymal transition (EMT). However, the underlying mechanisms causing this are not entirely clear. Long noncoding… Expand
Long non‐coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling
Chemotherapy is a reasonable alternative to cystectomy in patients with invasive and advanced bladder cancer. However, bladder cancer cells often develop drug resistance to these therapies, and ~ 50%… Expand
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models.
- P. Houghton, C. Stewart, +6 authors T. Brent
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 October 2000
The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts (four neuroblastomas, three rhabdomyosarcomas, and one glioblastoma). In all studies,… Expand
Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy
The recent discovery of a large number of histone methyltransferases reveals important roles of these enzymes in regulating tumor development and progression. SMYD3, a histone methyltransferase, is… Expand
microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog.
- M. Tan, X. Mu, +4 authors J. Qiu
- Biology, Medicine
- Biochemical and biophysical research…
- 5 February 2017
Accumulating evidence has linked deregulation of microRNA-495 (miR-495) to tumorigenesis; however, its function in tumor progression is controversial. This work was undertaken to explore the… Expand
A retrospective comparison of thulium laser en bloc resection of bladder tumor and plasmakinetic transurethral resection of bladder tumor in primary non-muscle invasive bladder cancer
Bladder cancer is currently considered the most common malignancy of the urinary tract. Thulium laser en bloc resection of bladder tumor (TmLRBT) and plasmakinetic transurethral resection of bladder… Expand
Androgen receptor‐regulated miRNA‐193a‐3p targets AJUBA to promote prostate cancer cell migration
Background Dysregulation of microRNA (miRNA) expression is implicated in cancer development and progression by modulating oncogenes or tumor suppressors at the post‐transcriptional level.
Downregulation of Homeodomain‐Interacting Protein Kinase‐2 Contributes to Bladder Cancer Metastasis by Regulating Wnt Signaling
Homeodomain‐interacting protein kinase‐2 (Hipk2) has been shown to have important regulatory roles in cancer biology, such as cancer cell proliferation, cell cycle, and cell invasion. However, the… Expand
Functional roles and potential clinical application of miRNA‐345‐5p in prostate cancer
MicroRNAs (miRNAs) are small non‐coding RNAs, which negatively regulate gene expression and impact prostate cancer (PCa) growth and progression. Circulating miRNAs are stable and detectable in… Expand
The CXCL12 G801A polymorphism and cancer risk: evidence from 17 case-control studies.
CXCL12 has been implicated in human carcinogenesis, but the association between the most-studied G801A polymorphism (rs1801157) and the risk of various cancers was reported with inconclusive results.… Expand