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HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
TLDR
This work has identified four HIV-1 and HIV-2 cross-reactive peptide epitopes, presented to CTL from HIV-infected Gambians by HLA-B35 (the most common Gambian class I HLA molecule), which may represent protective immunity against HIV infection. Expand
Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules1
TLDR
The present study showed the existence of three memory subsets and the pathway for their differentiation, and suggested that the Per−GraA−GraB−, Per−/lowGraA+GraB+, and Perlow GraA+ GraB+ cells were central memory, early effector memory, and late effectorMemory T cells, respectively. Expand
Adaptation of HIV-1 to human leukocyte antigen class I
TLDR
This process of viral adaptation may dismantle the well-established HLA associations with control of HIV infection that are linked to the availability of key epitopes, and highlights the challenge for a vaccine to keep pace with the changing immunological landscape presented by HIV. Expand
Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-171
TLDR
Analysis of the in vitro induction of Tc17 cells showed that these cells were induced from theCD27+CD28+CD45RA+ naive subset and that they expressed the CD27−CD28 + CD45RA− and CCR6+ phenotype, which indicates that Tc 17 cells have a unique phenotype and suggest that they differentiate from the same precursors that differentiate into IFN-γ-producing CD8+ T cells. Expand
Identification of multiple HIV‐1 cytotoxic T‐cell epitopes presented by human leukocyte antigen B35 molecules
TLDR
Nine HLA‐B35‐restricted HIV‐1 CTL epitopes that are associated with the accelerated progression of AIDS using a reverse immunogenetic approach were identified and will be useful in studies for immunopathogenesis of AIDS. Expand
Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase
TLDR
Molecular modeling analysis shows that residue 348 is proximal to the NNRTI-binding pocket and to a flexible hinge region at the base of the p66 thumb that may be affected by the N348I mutation, which further highlight the role of connection subdomain residues in drug resistance. Expand
Cutting Edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells1
TLDR
The results suggest that the IL-8-CXCR1 pathway plays an important role in the homing of effector CD8+ T cells. Expand
Differentiation of Human CD8+ T Cells from a Memory to Memory/Effector Phenotype1
TLDR
The presence of a CD27−CD28+ subset with a CCR5+CCR7− phenotype implies a specialized role for this subset in the differentiation of CD8+ T cells. Expand
Excessive function of peripheral blood neutrophils from patients with Behçet's disease and from HLA-B51 transgenic mice.
TLDR
The HLA-B51 molecule itself may be responsible, at least in part, for neutrophil hyperfunction in Behçet's disease. Expand
Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function
TLDR
HCMV‐specific CD8+ T cells from healthy HCMV-seropositive individuals were predominantly found in effector and memory/effector subsets, indicating that HCMv‐specific effector CD8- T’cells are actively induced by HCMVs replication in healthy H CMV carriers. Expand
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