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Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1.
It is suggested that interference in O-mannosyl glycosylation is a new pathomechanism for muscular dystrophy as well as neuronal migration disorder.
Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes
- K. Ohtsubo, S. Takamatsu, M. Minowa, A. Yoshida, M. Takeuchi, J. Marth
- Biology, MedicineCell
- 29 December 2005
It is inferred that beta cell glucose-transporter glycosylation mediates a link between diet and insulin production that typically suppresses the pathogenesis of type 2 diabetes.
Biosensor discovery of thyroxine transport disrupting chemicals.
- G. Marchesini, A. Meimaridou, +6 authors A. Murk
- Chemistry, MedicineToxicology and applied pharmacology
- 1 October 2008
Results show that the hydroxylated metabolites of the ubiquitous PBDEs not only target the T4 transport at the TTR level, but also, and to a great extent, at the TBG level where most of the T 4 in humans is circulating.
Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter.
- N. Ishida, S. Yoshioka, Y. Chiba, M. Takeuchi, M. Kawakita
- Biology, MedicineJournal of biochemistry
- 1 July 1999
Comparison among UDP-galactose, CMP-sialic acid, and UDP-GlcNAc transporters from several organisms enabled us to identify residues highly conserved among the transporers and residues specific for each group of transporter.
The NMR structure of stomagen reveals the basis of stomatal density regulation by plant peptide hormones.
It is shown that stomagen is composed of a loop and a scaffold containing three disulphide bonds, and that the scaffold is structurally required for their activity.
Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells.
- M. Takeuchi, S. Takasaki, +4 authors A. Kobata
- Biology, MedicineThe Journal of biological chemistry
- 15 March 1988
It is proved, for the first time, that recombinant technique can produce glycoprotein hormone whose carbohydrate structures are common to the major sugar chains of the native one.
Loss of Disialyl Lewisa, the Ligand for Lymphocyte Inhibitory Receptor Sialic Acid-Binding Immunoglobulin-Like Lectin-7 (Siglec-7) Associated with Increased Sialyl Lewisa Expression on Human Colon…
The results indicate that the transition of carbohydrate determinants from disialyl Lewisa-dominant status to sialylLewisa-Dominant status on malignant transformation has a dual functional consequence: the loss of normal cell-cell recognition between mucosal epithelial cells and lymphoid cells on one hand and the gain of E-selectin binding activity on the other.
Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells.
- M. Takeuchi, N. Inoue, +7 authors A. Kobata
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 October 1989
A positive correlation between the in vivo activity of EPO and the ratio of tetraantennary to biantennary oligosaccharides is found and suggests that higher branching of the N-linked sugar chains is essential for effective expression of in vivo biological activity ofEPO.
M3 receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland
- K. Ikeda, Seiji Kobayashi, +4 authors K. Honda
- Chemistry, MedicineNaunyn-Schmiedeberg's Archives of Pharmacology
- 14 June 2002
M3 receptor antagonism by solifenacin could be bladder-selective and may provide new approaches to the pharmacotherapy of overactive bladder, as well as study the tissue selectivity between bladders and salivary glands.
Characterization of Yeast Yea4p, a Uridine Diphosphate-N-acetylglucosamine Transporter Localized in the Endoplasmic Reticulum and Required for Chitin Synthesis*
- S. Roy, Y. Chiba, M. Takeuchi, Y. Jigami
- Medicine, BiologyThe Journal of Biological Chemistry
- 5 May 2000
The results indicate that YEA4 encodes an ER-localized UDP-GlcNAc transporter that is required for cell wall chitin synthesis in S. cerevisiae.