Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
It is shown that retinal ganglion cells innervating the SCN are intrinsically photosensitive, and depolarized in response to light even when all synaptic input from rods and cones was blocked.
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other non–image-forming visual functions.
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
It is reported that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged.
A Novel Connection between Rods and ON Cone Bipolar Cells Revealed by Ectopic Metabotropic Glutamate Receptor 7 (mGluR7) in mGluR6-Deficient Mouse Retinas
It is shown that a certain type of ON cone bipolar cell forms ribbon-associated synapses not only with cones, but also rods, which suggest that, in mice, rod signals bifurcate into a third ON and OFF pathway, thought to transmit fast and moderately light-sensitive rod signals, functioning to smooth out the intensity changes at the scotopic–mesopic interface.
Changes in Visual Response Properties of Cat Retinal Ganglion Cells within Two Weeks after Axotomy
The results suggest that the major events occurring shortly after axotomy are significant loss of synaptic inputs from afferent neurons in the retina and/or changes of membrane properties of axotomized RGCs, which can also explain lower spontaneous activities and weaker visual responses of axotomyized R GCs.
Ectopic synaptic ribbons in dendrites of mouse retinal ON- and OFF-bipolar cells
The ectopic distribution of synaptic ribbons in dendrites of mouse retinal bipolar cells was examined by using genetic ablation of metabotropic glutamate receptor subtype 6 (mGluR6), electron microscopy, and immunocytochemistry and the presence of ectopic ribbons was correlated with an increase in the roundness of the invaginating dendrite of the rod bipolar cells.
Hattar Projections , and Intrinsic Photosensitivity Melanopsin-Containing Retinal Ganglion Cells : Architecture
This paper presents a meta-analyses of the immune system’s response to chemotherapy and shows clear patterns of decline in response to treatment-side effects of chemotherapy and also investigates the role of immune checkpoints in this response.
Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice
A new intraretinal recording system with multiple-barreled electrodes for pharmacological studies on cat retinal ganglion cells
Possible Role for Melanopsin in Photoentrainment of the Circadian Clock in Rodents