• Publications
  • Influence
Biogenesis and functions of aminocarboxypropyluridine in tRNA
TLDR
It is found that the Escherichia coli yfiP gene, which is renamed tapT (tRNA aminocarboxypropyltransferase), is responsible for acp3U formation in tRNA, a highly conserved modification found in variable- and D-loops of tRNAs. Expand
Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability
TLDR
It is shown that FTSJ1 is responsible for 2′-O-methylation of 11 species of cytosolic transfer RNAs at the anticodon region, and these modifications are abolished in Ftsj1 knockout (KO) mice and XLID patient–derived cells. Expand