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Biogenesis and functions of aminocarboxypropyluridine in tRNA
It is found that the Escherichia coli yfiP gene, which is renamed tapT (tRNA aminocarboxypropyltransferase), is responsible for acp3U formation in tRNA, a highly conserved modification found in variable- and D-loops of tRNAs. Expand
Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability
It is shown that FTSJ1 is responsible for 2′-O-methylation of 11 species of cytosolic transfer RNAs at the anticodon region, and these modifications are abolished in Ftsj1 knockout (KO) mice and XLID patient–derived cells. Expand