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jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression.
Spatiotemporal regulation of cell proliferation is necessary for normal tissue development. The molecular mechanisms, especially the signaling pathways controlling the cell cycle machinery, remain… Expand
Disulfide Bond Mediates Aggregation, Toxicity, and Ubiquitylation of Familial Amyotrophic Lateral Sclerosis-linked Mutant SOD1*
- J. Niwa, S. Yamada, +6 authors G. Sobue
- Chemistry, Medicine
- Journal of Biological Chemistry
- 21 September 2007
Mutations in the Cu/Zn-superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (ALS) through the gain of a toxic function; however, the nature of this toxic function remains… Expand
A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells.
- M. Abe, T. Sugiura, M. Takahashi, K. Ishii, M. Shimoda, K. Shirasuna
- Biology, Medicine
- Cancer letters
- 8 August 2008
In this study, we analyzed the effect of the metastasis suppressor CD82/KAI-1, a member of the tetraspanin superfamily, on intercellular adhesion on cancer cells. The newly established invasion assay… Expand
Ameloblastic carcinoma, secondary type: a case report.
- K. Karakida, T. Aoki, +5 authors Y. Ota
- Oral surgery, oral medicine, oral pathology, oral…
- 1 December 2010
Malignant variants of ameloblastoma include metastasizing ameloblastoma, which microscopically appears benign but has metastasized and ameloblastic carcinoma that exhibits malignant histopathologic… Expand
MRI analysis of chronological changes in free-flap volume in head and neck reconstruction by volumetry.
- Y. Sakamoto, T. Takahara, +10 authors M. Miyasaka
- The Tokai journal of experimental and clinical…
- 20 March 2014
OBJECTIVE To evaluate changes in flap volumes for head and neck cancer patients by MRI. METHODS MRI examinations of a total of 21 head and neck cancer patients (13 males and 8 females; average age,… Expand
Analysis of risk factors for surgical-site infections in 276 oral cancer surgeries with microvascular free-flap reconstructions at a single university hospital
- K. Karakida, T. Aoki, +5 authors M. Miyasaka
- Journal of infection and chemotherapy : official…
- 1 September 2010
The purpose of this study was to elucidate the risk factors for surgical-site infection (SSI) in oral cancer surgery with microvascular free-flap reconstructions and to propose appropriate SSI… Expand
Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology
- R. Shiurba, K. Ishiguro, M. Takahashi, K. Sato, R. Nixon
- Chemistry, Medicine
- Brain Research
- 21 October 1996
One unique phosphorylation site consistently found in paired helical filament tau, serine 413, is modified by tau protein kinase I/glycogen synthase kinase-3 beta but no other known tau kinase. Here… Expand
Distribution of tau protein kinase I/glycogen synthase kinase-3β, phosphatases 2A and 2B, and phosphorylated tau in the developing rat brain
When trying to elucidate the role played by tau protein kinase I/glycogen synthase kinase-3beta (TPKI/GSK-3beta) in tau phosphorylation, it is important to consider the balance that exists between… Expand
Correlation Between Salivary &agr;-Amylase Activity and Pain Scale in Patients With Chronic Pain
- Shyuichi Shirasaki, H. Fujii, +4 authors K. Hirota
- Regional Anesthesia & Pain Medicine
- 27 November 2006
Background and Objectives: The visual analog scale (VAS) is commonly used to assess pain intensity. However, the VAS is of limited value if patients fail to reliably report. Objective assessments are… Expand
VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker.
- T. Sugiura, Y. Inoue, +4 authors K. Shirasuna
- International journal of oncology
- 1 September 2007
The prognosis of patients with oral squamous cell carcinoma (SCC) is influenced by the presence of lymph node metastasis. In this study, we analyzed the relationship between lymphangiogenesis and the… Expand