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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.
To the Editor: Most cases of Parkinson's disease are considered sporadic and idiopathic, although there is evidence of familial aggregation, and several monogenic forms have been identified.1 Recen...
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Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues.
OBJECTIVE To provide recommendations to patients, physicians, and other health care providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). DATA SOURCES ANDExpand
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STN-DBS FREQUENCY EFFECTS ON FREEZING OF GAIT IN ADVANCED PARKINSON DISEASE To the Editor: We read with interest the article by Moreau et al. describing a new treatment for severe freezing of gaitExpand
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Subthalamic deep brain stimulation and impulse control in Parkinson’s disease
Background and purpose:  Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose ofExpand
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Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection.
Peripheral nerve disorders are among the most common neurological complications of HIV disease. Distal sensory polyneuropathy (DSP) is the most common form of neuropathy in patients with AIDS and canExpand
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Impaired sequence learning in carriers of the DYT1 dystonia mutation
Previous positron emission tomography (PET) studies have shown that nonmanifesting carriers of the DYT1 dystonia mutation express an abnormal pattern of resting glucose metabolism. To determineExpand
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Botulinum toxin type A in the treatment of upper extremity spasticity
Spasticity is a disorder of excess muscle tone associated with CNS disease. We hypothesized that botulinum toxin, a neuromuscular blocking agent, would reduce tone in spastic muscles after stroke.Expand
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Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers.
BACKGROUND Since the Food and Drug Administration approved DBS, there has been a surge in the number of centers providing the procedure. There is currently no consensus regarding appropriateExpand
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Calculating total electrical energy delivered by deep brain stimulation systems
Moro and colleagues should be commended for their recent article in Annals of Neurology on deep brain stimulation for Huntington's disease, the latest contribution to their ongoing effort to use constant energy paradigms to optimize DBS parameters and to determine which parameters have the most impact on clinical outcomes. Expand
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Peripheral nerve function in HIV infection: clinical, electrophysiologic, and laboratory findings.
OBJECTIVE To determine the effects of immunodeficiency, nutritional status, and concurrent systemic disease on peripheral nerve function in acquired immunodeficiency syndrome. DESIGN Survey ofExpand
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