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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
The results indicate that euchromatic H3-K9 methylation regulated by G9a is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes. Expand
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
The data underscore the selective presence of distinct histone lysine methylation states in partitioning chromosomal subdomains but also reveal a surprising plasticity in propagating methylation patterns in eukaryotic chromatin. Expand
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
It is revealed that G9a and GLP cooperatively exert H3-K9 methyltransferase function in vivo, likely through the formation of higher-order heteromeric complexes. Expand
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET
It is proposed that a DNA-methylation-independent pathway involving KAP1 and ESET/ESET-mediated H3K9me3 is required for proviral silencing during the period early in embryogenesis when DNA methylation is dynamically reprogrammed. Expand
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos
PGC7 protects 5mC from Tet3-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 lysine 9 in mice, and imprinted loci that are marked with H3K9me2 in mature sperm are protected by PGC7 binding in early embryogenesis. Expand
H3K9 methyltransferase G9a and the related molecule GLP.
The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase (HKMT), was reported in 2000, and recently, many important studies have reported that G9a and GLP play critical roles in various biological processes. Expand
Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice
It is suggested the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs. Expand
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
- M. Tachibana, Y. Matsumura, Mikiko Fukuda, H. Kimura, Y. Shinkai
- Biology, Medicine
- The EMBO journal
- 22 October 2008
This work has provided the first clear evidence that G9a/GLP suppresses transcription by independently inducing both H3K9 and DNA methylation. Expand
Methyl-CpG Binding Domain 1 (MBD1) Interacts with the Suv39h1-HP1 Heterochromatic Complex for DNA Methylation-based Transcriptional Repression*
- N. Fujita, Sugiko Watanabe, +5 authors M. Nakao
- Biology, Medicine
- Journal of Biological Chemistry
- 27 June 2003
Data indicate that MBD1 may tether the Suv39h1-HP1 complex to methylated DNA regions, suggesting the presence of a pathway from DNA methylation to the modifications of histones for epigenetic gene regulation. Expand
Functional dynamics of H3K9 methylation during meiotic prophase progression
It is shown that H3K9me1 and 2 are dynamically and sex‐differentially regulated during the meiotic prophase, which strongly suggests that a specific set of H3k9 methyltransferase(s) and demethylase (s) coordinately regulate gametogenesis. Expand