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Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity
TLDR
An unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families are discovered.
Cedar Virus: A Novel Henipavirus Isolated from Australian Bats
TLDR
In isolation and characterization of a new paramyxovirus from pteropid bats, Cedar virus (CedPV), which shares significant features with the known henipaviruses, and preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV.
Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats
TLDR
It is demonstrated that bat IFN-α genes are constitutively expressed in unstimulated bat tissues and cells and their expression is unaffected by viral infection, providing evidence for a unique IFN system that may be linked to the ability of bats to coexist with viruses.
Establishment, Immortalisation and Characterisation of Pteropid Bat Cell Lines
TLDR
A retroviral system is used to immortalise cells via the transfer and stable production of the Simian virus 40 Large T antigen and the human telomerase reverse transcriptase protein and the approaches developed and optimised should be applicable to bats of other species.
Identification of diverse groups of endogenous gammaretroviruses in mega- and microbats.
TLDR
The discovery of RNA transcripts from two putative endogenous gammaretroviruses in frugivorous and insectivorous bat species indicates that bats harbour distinct gammeretrovirus and may have played an important role as reservoir hosts during the diversification of mammalian gammarenrovirus.
Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis
TLDR
Results confirm the importance of PLD as a protective antigen and demonstrate both the potential for developing an oral caseous lymphadenitis vaccine and C. pseudotuberculosis Toxminus as a live vaccine vector.
The immune gene repertoire of an important viral reservoir, the Australian black flying fox
TLDR
This study describes the immune transcriptome of the Australian flying fox, Pteropus alecto, providing an important resource for identification of genes involved in a range of activities including antiviral immunity, and provides a survey of expressed bat genes that complement existing bat genomic data.
Vaccine Potential of Attenuated Mutants ofCorynebacterium pseudotuberculosis in Sheep
TLDR
The results suggest that aroQ mutants of C. pseudotuberculosis are attenuated with regard to both lymph node persistence and vaccination site reactogenicity and may be overly attenuated for use as a CLA vaccines or as vaccine vectors.
Identification of diverse full-length endogenous betaretroviruses in megabats and microbats
TLDR
It is revealed that a diverse range of betaretroviruses have circulated in bats for most of their evolutionary history, and cluster with extant betaretoviruses of divergent mammalian lineages suggesting that their distribution may be largely unrestricted by host species barriers.
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