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Global biogeographic sampling of bacterial secondary metabolism
Recent bacterial (meta)genome sequencing efforts suggest the existence of an enormous untapped reservoir of natural-product-encoding biosynthetic gene clusters in the environment. Here we use the
Diketopiperazines produced by an Aspergillus fumigatus Brazilian strain
TLDR
The relative and absolute stereochemistries were determined on the basis of NOESY experiments and by using a modified version of Marfey's method using HPLC, respectively.
Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia.
TLDR
A total of 39 endophytic fungi have been isolated from Viguiera arenaria and Tithonia diversifolia, both collected in São Paulo State, Brazil, and nectriapyrone showed relevant cytotoxic activity against both human T leukemia and melanoma tumor cell lines.
The antimicrobial potential of Streptomyces from insect microbiomes
TLDR
The antimicrobial potential of insect-associated Streptomyces is uncovered and a compound, cyphomycin, active against multidrug-resistant fungal pathogens is identified, indicating host microbiomes are feasible sources for drug discovery.
Endophytic Fungi: Natural Products, Enzymes and Biotransformation Reactions
TLDR
Recent data on endophytes research as a source of novel and bioactive natural products, as producers of enzymes and their use on biotransformation processes are summarized.
A Mixed Culture of Endophytic Fungi Increases Production of Antifungal Polyketides
TLDR
Biological activity assays revealed that stemphyperylenol can cause cytotoxic effects against N. sphaerica, although no phytotoxicity was observed in the host plant Smallanthus sonchifolius, even at concentrations much higher than those toxic to the fungus.
Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans
TLDR
Endophytic fungi isolated from the red seaweed Bostrychia radicans were studied and the presence of promising metabolites indicate that these natural products should be considered in the development of new antibiotics.
Chemical signaling involved in plant-microbe interactions.
TLDR
Different plant-microbe associations from colonization to microbial establishment processes in plants along with future prospects, including agricultural benefits are described.
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