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Combinatory Therapy Antimicrobial Peptide-Antibiotic to Minimize the Ongoing Rise of Resistance
This article focuses on the main aspects of the combinatory therapy antimicrobial peptide (AMP)-antibiotic to treat infectious diseases. Expand
Synthesis and properties of cyclic gomesin and analogues
Because of its high therapeutic index, easy synthesis and lower cost, the [Thr2,6,11,15,d‐Pro9]‐Gm analogue remains the best active Gm‐derived AMP developed so far; nevertheless, its elevated instability in human serum may limit its therapeutic potential. Expand
Radical acylation of L-lysine derivatives and L-lysine-containing peptides by peroxynitrite-treated diacetyl and methylglyoxal
The observed formylation of L-Lys containing peptides by methylglyoxal never reported to occur in amino acid residues of peptides and proteins is suggested, suggesting the possibility of radical acylations of proteins in epigenetic processes. Expand
New iminodibenzyl derivatives with anti-leishmanial activity.
This work presents the synthesis and characterization of new iminodibenzyl derivatives (dado) with ethylenediamine (ea), ethanolamine (en) and diethylenetriamine (dien) and their copper(II) complexes and indicated that the complexes were highly lipophilic. Expand
Desferrioxamine-caffeine (DFCAF) as a cell permeant moderator of the oxidative stress caused by iron overload
This work successfully prepared and described DFO-caffeine, a conjugate with iron scavenging ability, antioxidant properties and enhanced permeation in the HeLa cell model. Expand
Cell penetrating peptide (CPP)-conjugated desferrioxamine for enhanced neuroprotection: synthesis and in vitro evaluation.
DFO antioxidant and iron binding properties were preserved and its bioavailability was increased upon CPP conjugation, which opens new therapeutic possibilities for neurodegenerative processes associated with brain iron overload. Expand
Self‐assembled penetratin‐deferasirox micelles as potential carriers for hydrophobic drug delivery
The conjugate of penetratin, a cell‐penetrating peptide with blood‐brain barrier permeability, and deferasirox, a hydrophobic iron chelator, self‐assembles to form micelles at a very low concentration, indicating the potential of CPP‐drug conjugates for use as nanocarriers. Expand
Mitochondria-penetrating peptides conjugated to desferrioxamine as chelators for mitochondrial labile iron
Results indicate that mtDFO could be promising compounds for amelioration of the disease symptoms of iron overload in mitochondria. Expand
Cadmium decreases the levels of glutathione and enhances the phytochelatin concentration in the marine dinoflagellate Lingulodinium polyedrum
A novel method for PC3 and PC4 synthesis is described here based on a Boc strategy, yielding peptides with purities higher than 97 %, which seems to be an efficient strategy of L. polyedrum to be protected against Cd environment contamination, since PC4 has more chelating sites and is structurally more stable than PC2 and PC3, the most abundant for other microalgae. Expand
Copper nanoparticles synthesized by thermal decomposition in liquid phase: the influence of capping ligands on the synthesis and bactericidal activity
We explored here the synthesis of copper nanoparticles (CuNPs) by thermal decomposition of copper(II) acetate in diphenyl ether in the presence of different capping ligands. To look for any specificExpand