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Cryopreserved Morulae can be used to Efficiently Generate Germline-transmitting Chimeras by Blastocyst Injection
The production of chimeric mice is a complex process, requiring the careful coordination of tissue culture cell growth, production of a large number (30–75) of competent blastocysts and theExpand
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Access to the Nucleus and Functional Association with c-Myc Is Required for the Full Oncogenic Potential of ΔEGFR/EGFRvIII*
Background: Expression of ΔEGFR, a mutant of EGFR in gliomas, correlates with poor prognosis. Results: Access to the nucleus is required for full oncogenicity of ΔEGFR, and nuclear ΔEGFR regulatesExpand
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Aberrant EGFR Signaling in Glioma
Dysregulation of receptor tyrosine kinase (RTK) signaling is a major contributor to cancer, including glioma (Pawson and Hunter 1994). In glioma, epidermal growth factor receptor (EGFR) is frequentlyExpand
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Contribution of Ectodomain Mutations in Epidermal Growth Factor Receptor to Signaling in Glioblastoma Multiforme
.................................................................................................................v TABLE OFExpand
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Extracellular Domain Mutations in EGFR Occur Uniquely in Glioblastoma and Favor Ligand-independent Formation of the Active State
Previous work has shown that these mutations promote tumor growth and ligand-independent EGFR signaling.2 To explore how extracellular missense mutations cause these phenotypes, structural andExpand
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