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Gender Differences in Cancer Susceptibility: An Inadequately Addressed Issue
The gender difference in cancer susceptibility is one of the most consistent findings in cancer epidemiology. Hematologic malignancies are generally more common in males and this can be generalizedExpand
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An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males.
The interferon regulatory factor (IRF) family of DNA-binding proteins regulates expression of interferon-inducible genes with roles in the immune response and carcinogenesis. IRF4 is involved in theExpand
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Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia.
Genetic and environmental factors play an interactive role in the development of childhood acute lymphoblastic leukemia (ALL). Since the demonstration of a major histocompatibility complex (MHC)Expand
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TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.
Genomic and immunologic surveillance mechanisms are crucial in protection from cancer. The tumor suppressor protein p53, encoded by TP53, is a major regulator of genome surveillance. Among theExpand
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Human major histocompatibility complex contains several leukemia susceptibility genes.
In mice, homozygosity for the Mhc haplotype H-2k is associated with increased susceptibility to spontaneous and virus-induced leukemia, lymphoma and other neoplasms in the predisposed host. TheExpand
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Influence of the major histocompatibility complex on age at onset of chronic lymphoid leukaemia.
The major histocompatibility complex is one of the interactive factors in the multifactorial model of carcinogenesis. Its main influence in experimental models is on the age at onset of malignancies.Expand
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Increased heterozygosity for MHC class II lineages in newborn males
In plants, fungi and marine invertebrates, there are genetic compatibility systems to ensure diversity in the offspring. The importance of genetic compatibility in gametic union and selectiveExpand
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Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk
Our original studies reported an association between the iron‐metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effectExpand
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A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.
Previous studies reported significant HLA-DR associations with various leukemias one of which is with HLA-DRB4 (DR53) family in male patients with childhood ALL. We have HLA-DR-typed 212 high-risk orExpand
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Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection
BackgroundsThe association of human leukocyte antigen (HLA) genes with the outcome of hepatitis C virus (HCV) infection may be modified by ethnic and geographical differences.ResultsHLA-A, -C, -DRB1Expand
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