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Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities*
Background: Methicillin-resistant Staphylococcus aureus (MRSA) PK has been recently identified as a potential novel antimicrobial drug target. Results: Screening of a marine extract library led toExpand
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Drug Discovery in Africa: Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs
drug discovery in africa impacts of genomics natural drug discovery in africa zanjan university of medical drug discovery in africa pimccheck drug discovery in africa home springer drug discovery inExpand
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The cardioprotective effects of marrubiin, a diterpenoid found in Leonotis leonurus extracts.
ETHNOPHARMACOLOGICAL RELEVANCE Leonotis leonurus L. (Lamiaceae) is used as a traditional medicine for a variety of ailments in South Africa. The diterpene marrubiin is the major product constituentExpand
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Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate.
Mandelalides A-D are variously glycosylated, unusual polyketide macrolides isolated from a new species of Lissoclinum ascidian collected from South Africa, Algoa Bay near Port Elizabeth and theExpand
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Measuring and optimising umckalin concentration in wild-harvested and cultivated Pelargonium sidoides (Geraniaceae)
Abstract Pelargonium sidoides DC. (Geraniaceae) root extracts are used locally and globally as herbal medicines. Subsequently, high levels of wild root harvest in the years preceding this study, toExpand
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Cytotoxic pyrroloiminoquinones from four new species of South African latrunculid sponges.
An examination of organic extracts of four new species of South African latrunculid sponges, Tsitsikamma pedunculata, T. favus, Latrunculia bellae, and Strongylodesma algoaensis, yielded 13 known andExpand
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Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones
Marine invertebrates, algae, and microorganisms are prolific producers of novel secondary metabolites. Some of these secondary metabolites have the potential to be developed as chemotherapeuticExpand
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New Halogenated Sesquiterpenes from South African Specimens of the Circumtropical Sea Hare Aplysia dactylomela
An examination of the digestive gland extracts from two color variants of the circumtropical sea hare Aplysia dactylomela, collected off the Eastern Cape coast of South Africa, yielded four newExpand
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Antiesophageal Cancer Activity from Southern African Marine Organisms
Squamous cell esophageal cancer presents a significant health burden in many developing countries around the world. In South Africa, this disease is one of the most common causes of cancer‐relatedExpand
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Diversity of Bacterial Communities Associated with the Indian Ocean Sponge Tsitsikamma favus That Contains the Bioactive Pyrroloiminoquinones, Tsitsikammamine A and B
Tsitsikamma favus is a latrunculid sponge endemic to the coast of South Africa that produces unique pyrroloiminoquinones known as tsitsikammamines. Wakayin and makaluvamine A are structurally similarExpand
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