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Beyond the comparator model: A multifactorial two-step account of agency
Targeted next generation sequencing as a diagnostic tool in epileptic disorders
Purpose: Epilepsies have a highly heterogeneous background with a strong genetic contribution. The variety of unspecific and overlapping syndromic and nonsyndromic phenotypes often hampers a clear…
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients.
Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal recessive disease due to mutations in the senataxin gene, causing progressive cerebellar ataxia with peripheral neuropathy, cerebellar…
I move, therefore I am: A new theoretical framework to investigate agency and ownership
The Cerebellum Updates Predictions about the Visual Consequences of One's Behavior
Misattributions of agency in schizophrenia are based on imprecise predictions about the sensory consequences of one's actions.
- M. Synofzik, P. Thier, D. Leube, P. Schlotterbeck, A. Lindner
- PsychologyBrain : a journal of neurology
The notion that delusions of influence are based on imprecise internal predictions about the sensory consequences of one's actions is supported and it is suggested that such imprecising predictions prompt patients to rely more strongly on (and thus adapt to) external agency cues, in this case vision.
S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway
A role of S100B in the pathophysiology of Parkinson’s disease is demonstrated and Targeting S 100B may emerge as a potential treatment strategy in this disorder.
A Pan-European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats
In vitro reporter gene expression studies demonstrated significantly decreased transcriptional activity of C9orf72 with increasing number of normal repeat units, indicating that intermediate repeats might act as predisposing alleles and in favor of the loss‐of‐function disease mechanism.
Intensive coordinative training improves motor performance in degenerative cerebellar disease
- W. Ilg, M. Synofzik, D. Brötz, S. Burkard, M. Giese, L. Schöls
- Psychology, MedicineNeurology
- 1 December 2009
In patients with cerebellar ataxia, coordinative training improves motor performance and reduces ataxIA symptoms, enabling them to achieve personally meaningful goals in everyday life.
The experience of agency: an interplay between prediction and postdiction
The framework of optimal cue integration offers a promising approach that directly stimulates a wide range of experimentally testable hypotheses on agency processing in different subject groups.