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The scent of Mycobacterium tuberculosis.
Worldwide, tuberculosis (TB) kills nearly 2 million people annually, yet rapid diagnosis still relies on a 100-year-old method of sputum staining for acid-fast bacilli. The advent of solid phase… Expand
2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
BackgroundPseudomonas aeruginosa infections are associated with progressive life threatening decline of lung function in cystic fibrosis sufferers. Growth of Ps. aeruginosa releases a "grape-like"… Expand
The scent of Mycobacterium tuberculosis--part II breath.
Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium… Expand
Novel diagnostics: progress toward a breath test for invasive Aspergillus fumigatus.
In this paper we will briefly review some of the possible techniques for the development of a breath test for aspergillosis and describe progress made toward validating 2-Pentyl furan (2PF) as a… Expand
Investigation into the production of 2-Pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples.
Our objective was to identify, for diagnostic purposes, potential volatile biomarkers of human microbial pathogens. We analysed the head space of cultures of medically important bacterial and fungal… Expand
Detection of 2-pentylfuran in the breath of patients with Aspergillus fumigatus.
- S. Chambers, M. Syhre, D. Murdoch, F. McCartin, M. Epton
- Medicine, Biology
- Medical mycology
- 13 August 2009
Aspergillus fumigatus produces 2-pentylfuran (2-PF) when cultured on blood agar, nutrient agar and other media. As 2-PF is not known to be produced by mammalian metabolism we hypothesized that it is… Expand
Assessment of potential causes of falsely positive Mycobacterium tuberculosis breath test.
A suite of volatiles have previously been identified as specific markers of Mycobacterium tuberculosis metabolism in vitro. These markers - methyl phenylacetate, methyl p-anisate, methyl nicotinate,… Expand
Determining the limits and confounders for the 2-pentyl furan breath test by gas chromatography/mass spectrometry.
- S. Bhandari, S. Chambers, John Pearson, M. Syhre, M. Epton, Amy J Scott-Thomas
- Chemistry, Medicine
- Journal of chromatography. B, Analytical…
- 15 September 2011
Aspergillus fumigatus produces 2-pentyl furan (2-PF), a volatile compound not produced by many other pathogens or normal human metabolism. 2-Pentyl furan has been detected in the breath of patients… Expand
Discriminating NSCLC from COPD using patterns derived from an electronic nose
Introduction: Lung carcinoma is a leading cause of death. Early detection of the disease will improve the survival rate. An easy, inexpensive method for early detection or even screening at the… Expand
Biomarkers and other new methods for lung cancer
printing supported by . Visit Chiesi at Stand D.30 MONDAY, SEPTEMBER 26TH 2011 Conclusions: Exhaled breath analysis is a promising approach towards future non-invasive LC screening methods. By using… Expand