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El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving primarily motor neurons in the cerebral cortex, brainstem and spinal cord. The variability in clinicalExpand
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Electrodiagnostic criteria for diagnosis of ALS
A consensus meeting was held to determine the best use and interpretation of electrophysiological data in the diagnosis of ALS. The utility of needle EMG and nerve conduction studies was affirmed. ItExpand
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Changes in motor unit synchronization following central nervous lesions in man.
1. Single motor unit spike trains have been recorded during voluntary isometric contraction of the affected intrinsic hand muscles of patients with unilateral central nervous lesions. These have beenExpand
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Multifocal motor neuropathy
Recognition of new clinical phenotypes requires knowledge and clinical experience together with a new insight, often provided by an unexpected test result. Sometimes, as in multifocal motorExpand
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INJURY TO INNERVATION OF PELVIC FLOOR SPHINCTER MUSCULATURE IN CHILDBIRTH
71 women delivered at St Bartholomew's Hospital, London, were studied by electrophysiological tests of the innervation of the external anal sphincter muscle and by manometry. The investigations wereExpand
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Slowed conduction in the pudendal nerves in idiopathic (neurogenic) faecal incontinence
We have studied 30 patients with idiopathic (neurogenic) faecal incontinence using anorectal manometry and concentric needle and single fibre electromyographic methods. We have measured the terminalExpand
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Hippocampal and neocortical ubiquitin-immunoreactive inclusions in amyotrophic lateral sclerosis with dementia
Amyotrophic lateral sclerosis (ALS) patients with dementia were found to have ubiquitin-immunoreactive (IR) inclusions in the dentate granule cells of the hippocampus. These inclusions were alsoExpand
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Effect of vaginal delivery on the pelvic floor: A 5‐year follow‐up
We have studied the pelvic floor musculature and its innervation in 14 of 24 (58 per cent) multiparous women who had been recruited into a study of the effect of childbirth on the pelvic floor asExpand
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Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity.
Antibodies to ubiquitin have been used to search for evidence of abnormal protein degradation in amyotrophic lateral sclerosis--motor neuron disease (ALS). Anterior horn cell ubiquitin-immunoreactiveExpand
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Molecular mechanisms and phenotypic variation in RYR1-related congenital myopathies.
Dominant mutations in the skeletal muscle ryanodine receptor (RYR1) gene are well-recognized causes of both malignant hyperthermia susceptibility (MHS) and central core disease (CCD). More recently,Expand
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