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IL-6/IL-6 receptor system and its role in physiological and pathological conditions.
- M. Mihara, M. Hashizume, H. Yoshida, M. Suzuki, M. Shiina
- Biology, Medicine
- Clinical science
- 1 February 2012
IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and… Expand
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
- N. Kobayashi, K. Ueki, +19 authors T. Kadowaki
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 21 March 2011
Obesity and insulin resistance, the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation characterized by abnormal macrophage infiltration into… Expand
IL-6/sIL-6R trans-signalling, but not TNF-α induced angiogenesis in a HUVEC and synovial cell co-culture system
Angiogenesis in synovia is a characteristic of RA patients. We examined whether IL-6 or TNF-α induce tubule formation in a co-culture system of fibroblast-like synovial cells from RA patients… Expand
Sensitive response of cultured vascular smooth-muscle cells to cadmium cytotoxicity: comparison with cultured vascular endothelial cells and kidney epithelial LLC-PK1 cells.
Response to cadmium cytotoxicity of cultured bovine aortic smooth-muscle cells was compared with that of cultured bovine aortic endothelial cells and porcine kidney epithelial LLC-PK1 cells. The cell… Expand
Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule
We studied the influence of IL-6 on chemokine production from peripheral blood mononuclear cells (PBMC), fibroblastic synovial cells and human umbilical vessel endothelial cells (HUVEC). Moreover, we… Expand
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression.
In the present study, we investigated potential synergism between IL-6 and IL-1 for the production of matrix metalloproteinases (MMPs) by the synovial cell line SW982. Cells were cultured with… Expand
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis
We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was… Expand
Vitamin D Receptor Signaling Enhances Locomotive Ability in Mice
- Sadaoki Sakai, M. Suzuki, +6 authors Koichi Endo
- Journal of bone and mineral research : the…
- 1 January 2015
Bone fractures markedly reduce quality of life and life expectancy in elderly people. Although osteoporosis increases bone fragility, fractures frequently occur in patients with normal bone mineral… Expand
Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells.
- H. Yoshida, M. Hashizume, M. Suzuki, M. Mihara
- Biology, Medicine
- European journal of pharmacology
- 25 May 2010
T cell activation is crucial to the pathogenesis and progression of rheumatoid arthritis. Tumour necrosis factor-alpha (TNFalpha) and interleukin (IL)-6 inhibitors show marked efficacy in rheumatoid… Expand
Depletion of Hsp90β Induces Multiple Defects in B Cell Receptor Signaling*
Hsp90 participates in many distinct aspects of cellular functions and accomplishes these roles by interacting with multiple client proteins. To gain insight into the interactions between Hsp90 and… Expand