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Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats
BackgroundInsulin signaling and Tau protein phosphorylation in the hippocampi of young and old obese Zucker fa/fa rats and their lean controls were assessed to determine whether obesity-inducedExpand
Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats
Currently, much attention is focused on the influence of mitochondrial disturbances at the onset of depression. The goal of this study was to investigate the impact of prenatal stress (an animalExpand
Human monocyte subsets exhibit divergent angiotensin I‐converting activity
Immune cells may take part in the renin–angiotensin–aldosterone system (RAAS), which plays a pivotal role in the regulation of vascular tone and blood pressure. The aim of the study was to analyseExpand
Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin.
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance. Metformin, a widely known anti-diabetic drug, used for patients with type 2 diabetes mellitus, is also claimedExpand
Co-administration of dextromethorphan and morphine: reduction of post-operative pain and lack of influence on morphine metabolism.
We investigated co-analgesic effect of dextromethorphan in adolescent post-operative patients with idiopathic scoliosis. In a double-blind study, 60 patients with ASA physical status I-II wereExpand
The influence of AICAR ‐ direct activator of AMP‐activated protein kinase (AMPK) ‐ on liver proteome in apoE‐knockout mice
Abstract There is a growing body of evidence that altered functioning of apoE may aggravate cellular energy homeostasis and stress response, leading to oxidative stress, mitochondrial dysfunction,Expand
Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue.
The metabolic action of oxytocin has recently been intensively studied to assess the ability of the peptide to regulate energy homeostasis. Despite the obvious weight-reducing effect of oxytocinExpand
Kaempferol, but not resveratrol inhibits angiotensin converting enzyme.
Inhibition of angiotensin converting enzyme (ACE) has proved to be beneficial in the treatment of various cardiovascular disorders. The aim of this study was to evaluate ACE inhibitory potential ofExpand
The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression
The etiology of depression remains still unclear. Recently, it has been proposed, that mitochondrial dysfunction may be associated with development of mood disorders, such as depression, bipolarExpand
Ischemic preconditioning of skeletal muscle improves tissue oxygenation during reperfusion.
Ischemic preconditioning (IPC) renders tissue resistant to the deleterious effects of prolonged ischemia and reperfusion by prior exposure to brief, repeated periods of vascular occlusion. AlthoughExpand