Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.
The strength of the evidence that untreated subclinical thyroid disease is associated with clinical symptoms and adverse clinical outcomes was assessed and recommendations for clinical practice developed and insufficient evidence to support population-based screening was found.
Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism.
- M. Surks, J. Hollowell
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 December 2007
TSH distribution progressively shifts toward higher concentrations with age, and the prevalence of subclinical hypothyroidism may be significantly overestimated unless an age-specific range for TSH is used.
Drugs and thyroid function.
Testing of thyroid function is common in clinical practice. Many patients who are tested, including those who have or are receiving treatment for thyroid disease, take medications that may affect…
Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital.
These findings suggest that increased thyroxine flux in phenobarbital-treated animals is secondary to primary stimulation of hepatocellular binding, which may be an important determinant of hormone turnover and, possibly, of hormonal action.
Subclinical thyroid disease.
American Thyroid Association guidelines for use of laboratory tests in thyroid disorders.
In sick patients, a normal or raised serum free thyroxine estimate together with a normal level of serum thyrotropin suggests that the patient has neither hypothyroidism nor thyrotoxicosis.
An approach for development of age-, gender-, and ethnicity-specific thyrotropin reference limits.
This study provides a method to determine TSH limits in individual patients of different ages, gender, and REG criteria whose AB status is uncertain and it will enable clinicians to better classify patients within their subpopulation-specific TSH reference range.
Subclinical thyroid disease: clinical applications.
Subclinical hypothyroidism and hyperthyroidism are diagnoses based on laboratory evaluation with few if any clinical signs or symptoms and patient preferences are important in deciding on management of subclinical disease.
Tissue differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain, spleen, and testis.
Using a previously reported in vivo isotopic displacement technique, we have demonstrated limited nuclear binding sites for L-triiodothyronine (T3) in the following rat tissues: liver, kidney, heart,…
Specific nuclear triiodothyronine binding sites in rat liver and kidney.
- J. Oppenheimer, D. Koerner, H. Schwartz, M. Surks
- Biology, PhysicsJournal of Clinical Endocrinology and Metabolism
- 1 August 1972
The results indicate the presence of relatively specific binding sites for T3 in the nuclei of rat liver and kidney as well as other ultracentrifugal fractions.