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TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma
Transforming growth factor beta 1 (TGF-β1) is the most potent inhibitor of myogenic differentiation (MyoD) of rhabdomyosarcoma (RMS); however, the underlying mechanisms of this inhibition remainExpand
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Chondrocyte hypertrophy in skeletal development, growth, and disease.
  • M. Sun, F. Beier
  • Biology, Medicine
  • Birth defects research. Part C, Embryo today…
  • 1 March 2014
Most of our bones form through the process of endochondral ossification, which is tightly regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the various stages ofExpand
  • 64
  • 2
Recent developments in emerging therapeutic targets of osteoarthritis
Purpose of review Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in partExpand
  • 32
  • 2
Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes
Joint homeostasis failure can result in osteoarthritis (OA). Currently, there are no treatments to alter disease progression in OA, but targeting early changes in cellular behavior has greatExpand
  • 14
Nuclear receptors as potential drug targets in osteoarthritis
HighlightsNuclear receptors (NR) are ligand‐activated transcription factors.NRs are well‐characterized pharmacologically and are promising drug targets for OA.Recent studies have implicated a numberExpand
  • 4
Liver X Receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes
Abstract Objective Osteoarthritis (OA) is the most common type of arthritis and causes debilitating symptoms and decreased quality of life. A better understanding of the molecular mechanismsExpand
Scientific Overview on CSCI-CITAC Annual General Meeting and 2018 Young Investigators’ Forum
The 2018 Annual General Meeting (AGM) and Young Investigators’ Forum (YIF) of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association ofExpand
Liver X Receptor activation regulates genes involved in lipid homeostasis in developing chondrocytes
Objective Osteoarthritis (OA) is the most common type of arthritis and causes debilitating symptoms and decreased quality of life. Currently available treatment options target symptoms but do notExpand