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Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB.
TLDR
Xanthoangelol D may be useful for the treatment of various vascular diseases involved NF-kappaB activation and prepro ET-1 mRNA expression in PAECs. Expand
Differential Effects of Different Statins on Endothelin-1 Gene Expression and Endothelial NOS Phosphorylation in Porcine Aortic Endothelial Cells
TLDR
It is most likely that cerivastatin suppresses ET-1 production, possibly through an increase in eNOS activity and the subsequent nitric oxide production in PAECs, and suggest that cervastatin may have beneficial effects on ET- 1–related diseases. Expand
A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells
BAY 11-7082, an inhibitor of nuclear factor-kappaB (NF-kappaB), which prevents a step of the phosphorylation of inhibitory protein IkappaB bound to NF-kappaB, suppressed basal and tumor necrosisExpand
The role of nuclear factor-κB in the regulation of endothelin-1 production by nitric oxide
TLDR
The results suggest that NO modulates the endothelial endothelin-1 production, possibly through the regulation of NF-κB activation. Expand
The role of nuclear factor-kappa B in the regulation of endothelin-1 production by nitric oxide.
TLDR
It is suggested that NO modulates the endothelial endothelin-1 production, possibly through the regulation of NF-kappaB activation, through the inhibition of the inhibitory protein alpha, IkappaBalpha. Expand
A nuclear factor-kappaB inhibitor BAY 11-7082 suppresses endothelin-1 production in cultured vascular endothelial cells.
TLDR
Results indicate that the inhibition of NF-kappaB activation contributes to the suppressive effect of BAY 11-7082 on ET-1 gene expression andET-1 release, thereby suggesting that NF- kappaB plays an important role in the regulation of ET- 1 production. Expand