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Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*
We have identified a novel gene referred to asactivation-induced deaminase (AID) by subtraction of cDNAs derived from switch-induced and uninduced murine B lymphoma CH12F3-2 cells, more than 80% ofExpand
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Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs1
Mesenchymal stromal cells are crucial components of secondary lymphoid organs (SLOs). Organogenesis of SLOs involves specialized stromal cells, designated lymphoid tissue organizer (LTo) in theExpand
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Lymph Node Fibroblastic Reticular Cells Construct the Stromal Reticulum via Contact with Lymphocytes
The sophisticated microarchitecture of the lymph node, which is largely supported by a reticular network of fibroblastic reticular cells (FRCs) and extracellular matrix, is essential for immuneExpand
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High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.
We have developed an efficient in vitro class switching system using a subclone (CH12F3) of the IgM+ CH12.LX lymphoma cell line. CH12F3 cells switched from surface IgM+ cells to surface IgA+ cells atExpand
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The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression
Pax5 activity is enhanced in activated B cells and is essential for class switch recombination (CSR). We show that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expressionExpand
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A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.
For efficient adaptive immunity, the lymph nodes (LNs) are equipped with a strategically organized microarchitecture, which is largely supported by the reticular network (RN). The RN can be clearlyExpand
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Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin
Class switch recombination (CSR) at the antibody immunoglobulin locus is regulated by germline transcription (GLT)–coupled modifications in the accessibility of the switch region, where CSR takesExpand
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Dysregulated expression of P1 and P2 promoter‐driven hepatocyte nuclear factor‐4α in the pathogenesis of human cancer
Hepatocyte nuclear factor‐4α (HNF4α) exists in multiple isoforms that are generated by alternative promoter (P1 and P2) usage and splicing. Here we establish monoclonal antibodies (mAbs) forExpand
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Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation
Front–rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which several proteins, including CD44 andExpand
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Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation
ABSTRACT Sialic acid (Sia) is a family of acidic nine-carbon sugars that occupies the nonreducing terminus of glycan chains. Diversity of Sia is achieved by variation in the linkage to the underlyingExpand
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