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Organization of lin Genes and IS6100 among Different Strains of Hexachlorocyclohexane-Degrading Sphingomonas paucimobilis: Evidence for Horizontal Gene Transfer
TLDR
DNA-DNA hybridization data revealed that most of the lin genes in these strains were associated with IS6100, an insertion sequence classified in the IS6 family and initially found in Mycobacterium fortuitum, which strongly suggests that all these strains acquired the linA gene through horizontal gene transfer mediated by IS6 100.
Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria
TLDR
Comparative microbiota analysis of mice with varying degrees of colonization resistance allowed us to identify intestinal ecosystem characteristics associated with susceptibility to S. enterica infection and provided evidence that this principle might be of general validity for invasion of bacteria in preformed gut ecosystems.
Cloning and Characterization of lin Genes Responsible for the Degradation of Hexachlorocyclohexane Isomers by Sphingomonas paucimobilis Strain B90
TLDR
The cloning and characterization of the halidohydrolase, dehydrogenase, and reductive dechlorinase genes from S. paucimobilis B90 revealed that they share ∼96 to 99% identical nucleotides with the corresponding genes of S. PaucIMobilis UT26, suggesting that S.paucimobiles B90 contains another pathway for the initial steps of β-HCH degradation.
Residues of hexachlorocyclohexane isomers in soil and water samples from Delhi and adjoining areas
TLDR
The contamination of mineral water could be due to heavy contamination of groundwater, which is used for making mineral water.
Mycobacterium tuberculosis Controls MicroRNA-99b (miR-99b) Expression in Infected Murine Dendritic Cells to Modulate Host Immunity*
TLDR
It is found that miR-99b expression was highly up-regulated in M. tuberculosis strain H37Rv-infected dendritic cells (DCs) and macrophages, which inhibits production of proinflammatory cytokines and augments TNF-α and TNFRSF-4 production.
Structure-based drug designing and immunoinformatics approach for SARS-CoV-2.
TLDR
Virtual screening of antiviral compounds targeting the spike glycoprotein (S), main protease (Mpro), and the SARS-CoV-2 receptor binding domain (RBD)-angiotensin-converting enzyme 2 (ACE2) complex of SARS, showing enhanced binding affinity to all the targets, revealed conformational changes associated with PC786 drug binding.
Global Transcriptome and Mutagenic Analyses of the Acid Tolerance Response of Salmonella enterica Serovar Typhimurium
TLDR
A transcriptome analysis of S. Typhimurium under the acid tolerance response (ATR) found differentially expressed genes to be associated with regulation, metabolism, transport and binding, pathogenesis, and motility, and provided a framework for further research on the subject.
A network map of Interleukin-10 signaling pathway
TLDR
A pathway resource by manually annotating the IL-10 induced signaling molecules derived from literature was developed, which can be freely accessed through NetPath, a resource of signal transduction pathways previously developed by the group.
Quantitative Proteomic and Phosphoproteomic Analysis of H37Ra and H37Rv Strains of Mycobacterium tuberculosis.
TLDR
This data provides a resource for further exploration of functional differences at molecular level between H37Rv and H37Ra, which will ultimately explain the molecular underpinnings that determine virulence in tuberculosis.
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