The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling
- Guozhi Bi, M. Su, Jian-Min Zhou
- Biology, ChemistryCell
- 11 May 2021
Coordinated regulation of heterochromatin inheritance by Dpb3–Dpb4 complex
This study demonstrates that the two conserved small histone-fold subunits of the DNA polymerase epsilon complex, Dpb3 and Dpb4, form a heterodimer and play an important role in coordinating the inheritance of histone hypoacetylation and H3K9 methylation during replication, and proposes a mechanism for how two processes are coordinated during replication.
Structure and activity of SLAC1 channels for stomatal signaling in leaves
- Ya-nan Deng, Hamdy Kashtoh, Yu-hang Chen
- Environmental ScienceProceedings of the National Academy of Sciences
- 29 April 2021
These studies define multiple sites of regulatory phosphorylation in the context of an atomic structure of the SLAC1 channel, providing a mechanistic understanding of the fine-tuning of channel activity and thereby of stomatal apertures in response to the environment.
Structural basis for activity of TRIC counter-ion channels in calcium release
- Xiaohui Wang, M. Su, Yu-hang Chen
- BiologyProceedings of the National Academy of Sciences
- 15 February 2019
It is shown that Ca2+ binding to TRIC channels stabilizes a nonconductive conformation; however, Ca2-free TRIC, as is generated during calcium release, frees a gating residue on a voltage-sensing helix to move out of blockage in response to membrane depolarization, which can restore polarization for continued calcium release.
Structural basis for conductance through TRIC cation channels
- M. Su, Feng Gao, Yu-hang Chen
- BiologyNature Communications
- 19 May 2017
Electrophysiology and mutagenesis studies show that prokaryotic TRICs have similar functional properties to those of mammalianTRICs and implicate the three-fold axis in the allosteric regulation of the channel.
Cryo-EM structure and electrophysiological characterization of ALMT from Glycine max reveal a previously uncharacterized class of anion channels
- Li Qin, Ling-Hui Tang, Yu-hang Chen
- BiologyScience Advances
- 1 March 2022
The study uncovers the molecular basis for a previously uncharacterized class of anion channels and provides insights into the gating and modulation of the ALMT12/QUAC1 anion channel.
Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading.
- Q. Dong, Feng-Xiang Yin, Fei Li
- Biology, ChemistryMolecules and Cells
- 6 October 2016
Molecular basis for the R-type anion channel QUAC1 activity in guard cells
- Li Qin, Lingrong Tang, Yu-hang Chen
- Biology
- 10 September 2021
The structural and functional analyses reveal that QUAC1 functions as an inward rectifying anion channel and suggests a mechanism for malate-mediated channel activation, which uncovers the molecular basis for a novel class of anion channels and provides insights into the gating and modulation of the R-type anionChannel.