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Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette‐smoking Mothers
The effects of maternal cigarette smoking on the transcriptome of human full‐term placentas were investigated by a microarray analysis. QPCR was performed for a selected set of metabolizing genes.Expand
Induction of cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) expression in rat brain by uncompetitive N-methyl-D-aspartate receptor antagonists.
The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor mediates fast excitatory neurotransmission, and agents that attenuate this function are neuroprotective, anesthetic, and psychotropic. ToExpand
Aflatoxin B1--a potential endocrine disruptor--up-regulates CYP19A1 in JEG-3 cells.
Previous studies have indicated that aromatase (CYP19A1) is involved in the metabolism of aflatoxin B1 (AFB1). We hypothesized that exposure to AFB1 contaminated food during pregnancy could disruptExpand
Dexmedetomidine preconditioning ameliorates kidney ischemia-reperfusion injury
Kidney ischemia‐reperfusion (I/R) injury is a common cause of acute kidney injury. We tested whether dexmedetomidine (Dex), an alpha2 adrenoceptor (α2‐AR) agonist, protects against kidney I/R injury.Expand
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry.
A simple and highly sensitive liquid chromatography/tandem mass spectrometric (LC/MS/MS) method was developed to compare endogenous cannabinoid levels in nematodes and in brains of rats and humans,Expand
AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study
Dysfunction of the brain glutamate system has been associated with alcoholism. Ionotropic glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) play an importantExpand
Whole genome microarray analysis of C. elegans rrf‐3 and eri‐1 mutants
We performed genome wide gene expression analysis on L4 stage Caenorhabditis elegans rrf‐3(pk1426) and eri‐1(mg366) mutant strains to study the effects caused by loss of their encoded proteins, whichExpand
Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family
Background: Cytochrome P450s (CYPs) are mono-oxygenases that metabolize endogenous compounds, such as fatty acids and lipid signaling molecules, and furthermore have a role in metabolism ofExpand
Prolyl Endopeptidase Is Involved in Cellular Signalling in Human Neuroblastoma SH-SY5Y Cells
Prolyl endopeptidase (PREP), probably acting through the inositol cycle, has been implicated in memory and learning. However, the physiological role of PREP is unknown. It has been shown that PREPExpand
Uncompetitive Antagonists of the N‐Methyl‐D‐aspartate (NMDA) Receptors Alter the mRNA Expression of Proteins Associated with the NMDA Receptor Complex
N-methyl-D-aspartate (NMDA) receptor function appears to be under complex control during physiological and pharmacological states. We have investigated the effects of acute administration ofExpand