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Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults
TLDR
Evidence-based recommendations for EoE diagnosis, treatment modalities, and patients’ follow up are proposed in the guidelines, and expert opinion and best clinical practice are provided.
Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis
TLDR
The show that activation of the CB2 receptor protects against experimental colitis in mice suggests a role for this receptor in normally limiting the development of colitis, and support the idea that theCB2 receptor may be a possible novel therapeutic target in inflammatory bowel disease.
The endogenous cannabinoid system protects against colonic inflammation.
TLDR
It is shown that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals that counteract proinflammatory responses, and this system represents a promising therapeutic target for the treatment of intestinal disease conditions characterized by excessive inflammatory responses.
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
TLDR
GLP-1 is suggested as a true incretin hormone and enterogastrone in humans because it tonically inhibits antroduodenal motility and mediates the postprandial inhibition of antral and stimulation of pyloric motility.
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
TLDR
It is shown that interstitial cells of Cajal, which generate spontaneous electrical slow waves and thus rhythmic contractions of the smooth musculature, are essential for transmission of signals from enteric neurons to gastrointestinal smooth muscle cells.
Eosinophilic colitis: epidemiology, clinical features, and current management
TLDR
The current knowledge of eosinophilic colitis, its epidemiology, clinical manifestations, diagnosis, and treatment is summarized.
Effect of cannabinoids on neural transmission in rat gastric fundus.
TLDR
The results of this study indicate that cannabinoids modulate excitatory cholinergic and inhibitory NANC neurotransmission in the rat gastric fundus.
Cannabis Use Provides Symptom Relief in Patients with Inflammatory Bowel Disease but Is Associated with Worse Disease Prognosis in Patients with Crohn's Disease
TLDR
Cannabis use is common in patients with IBD and subjectively improved pain and diarrheal symptoms, however, Cannabis use was associated with higher risk of surgery in Patients with Crohn's disease.
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
TLDR
In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases and reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis.
The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract
TLDR
An alternative and promising avenue for therapeutic applications resides in the treatment with CB1 receptor agonists that are unable to cross the blood–brain barrier, or with compounds that inhibit the degradation of endogenous ligands (endocannabinoids) of CB1 receptors, hence prolonging the activity of the endocannabinoid system.
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