DNA interchain cross-links formed by acrolein and crotonaldehyde.
- I. Kozekov, L. Nechev, T. Harris
- Chemistry, BiologyJournal of the American Chemical Society
- 8 January 2003
It is concluded that the cross-link is a mixture of imine and carbinolamine structures, which is one of the most serious types of damage in DNA since they are absolute blocks to replication.
Chemistry and Biology of DNA Containing 1,N2-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal
- I. Minko, I. Kozekov, T. Harris, C. Rizzo, R. Lloyd, M. Stone
- Chemistry, BiologyChemical Research in Toxicology
- 27 April 2009
Oligodeoxynucleotides containing structurally defined 1,N2-dG adducts of acrolein, crotonaldehyde, and 4-HNE were synthesized via a postsynthetic modification strategy and can be processed in mammalian cells by a mechanism not requiring homologous recombination.
Mutational properties of the primary aflatoxin B1-DNA adduct.
- E. A. Bailey, R. S. Iyer, M. Stone, T. Harris, J. Essigmann
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 February 1996
It is concluded that the AFB1-N7-Gua adduct, and not the apurinic site, has genetic requirements for mutagenesis that best explain mutations in aflatoxin-treated cells.
Characterization of DNA with an 8-oxoguanine modification
- Sreelekha K. Singh, Marta W Szulik, B. Gold
- Biology, ChemistryNucleic Acids Research
- 13 May 2011
Thermodynamic studies show that oxoG destabilizes DNA (ΔΔG of 2–8 kcal mol−1 over a 16–116 mM NaCl range) due to a significant reduction in the enthalpy term, and has a profound effect on the level and nature of DNA hydration indicating that the environment around anOxoG•C is fundamentally different than that found at G•C.
Interstrand DNA Cross‐Links Induced by α,β‐Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources
- M. Stone
- Chemistry
- 21 October 2008
Structure of (5'S)-8,5'-cyclo-2'-deoxyguanosine in DNA.
- Hai Huang, Rajat S Das, A. Basu, M. Stone
- Chemistry, BiologyJournal of the American Chemical Society
- 21 December 2011
The structure of an oligodeoxynucleotide duplex containing a site-specific S-cdG lesion placed opposite dC in the complementary strand was obtained by molecular dynamics calculations restrained by distance and dihedral angle restraints obtained from NMR spectroscopy.
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
- M. Stone, Young-jin Cho, C. Rizzo
- Chemistry, BiologyAccounts of Chemical Research
- 24 May 2008
Using a combination of chemical, spectroscopic, and computational methods, the chemistry of cross-link formation in duplex DNA is elucidated, revealing that the acrolein and crotonaldehyde cross-links consist primarily of interstrand carbinolamine linkages between the exocyclic amines of the two guanines located in the neighboring C.G and G.C base pairs.
Performance of cryogenic probes as a function of ionic strength and sample tube geometry.
- M. Voehler, Galen Collier, John K. Young, M. Stone, M. Germann
- PhysicsJournal of magnetic resonance (San Diego, Calif…
- 1 November 2006
Differential Stabilities and Sequence-Dependent Base Pair Opening Dynamics of Watson–Crick Base Pairs with 5-Hydroxymethylcytosine, 5-Formylcytosine, or 5-Carboxylcytosine
- Marta W Szulik, P. Pallan, M. Stone
- Biology, ChemistryBiochemistry
- 29 January 2015
Three modified Dickerson–Drew dodecamer sequences, amenable to crystallographic and spectroscopic analyses and containing the 5′-CG-3′ sequence associated with genomic cytosine methylation, were compared and lesion-specific differences observed in the DDD may be implicated in recognition of 5hmC, 5fC, or 5caC in DNA by TDG.
DNA cross‐link induced by trans‐4‐hydroxynonenal
- Hai Huang, I. Kozekov, M. Stone
- Chemistry, BiologyEnvironmental and Molecular Mutagenesis
- 1 July 2010
The conformations of the diastereomeric N2‐dG aldehydes, which are the reactive species involved in DNA cross‐link formation, have been calculated using molecular mechanics methods.
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