• Publications
  • Influence
How matrix metalloproteinases regulate cell behavior.
Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled. Expand
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
P phenotypically normal mammary epithelial cells with tetracycline-regulated expression of MMP3/stromelysin-1 (Str1) form epithelial glandular structures in vivo without Str1 but form invasive mesenchymal-like tumors with Str1, indicating that Str1 influences tumor initiation and alters neoplastic risk. Expand
Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
  • M. Sternlicht
  • Biology, Medicine
  • Breast Cancer Research
  • 5 December 2005
A clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided. Expand
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
It is suggested that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer. Expand
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
ADAM17 plays a crucial role in mammary morphogenesis by releasing AREG from mammary epithelial cells, thereby eliciting paracrine activation of stromal EGFR and reciprocal responses that regulate mammary encapsulated epithelial development. Expand
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis
Using pharmacologic and genetic approaches, it is found that mammary gland branching morphogenesis requires transient matrix metalloproteinase (MMP) activity for invasion and branch point selection and specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary glands branching morphogenic. Expand
Hormonal and local control of mammary branching morphogenesis.
This review discusses the current sense and understanding of the mechanisms as they pertain to mammary branching, with the caveat that many more aspects are still waiting to be solved. Expand
Myoepithelial Cells: Their Origin and Function in Breast Morphogenesis and Neoplasia
Data from the laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia are discussed. Expand
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Different contributions by MMPs to the progression of aggressive prostate tumor and to helping tumors cleverly find alternative routes to malignant progression are suggested. Expand
The human myoepithelial cell is a natural tumor suppressor.
The cumulative data suggest that myoepithelial cells are natural paracrine suppressors of invasion and metastasis and may specifically inhibit the progression of precancerous disease states to invasive cancer in vivo. Expand