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Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking.
- P. Thomsen, K. Roepstorff, M. Stahlhut, B. van Deurs
- Biology, MedicineMolecular biology of the cell
It is concluded that caveolae are not involved in constitutive endocytosis but represent a highly stable plasma membrane compartment anchored by the actin cytoskeleton.
Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton.
The F-actin cross-linking protein filamin is identified as a ligand for the caveolae-associated protein caveolin-1, and the actin network seems to be directly involved in the spatial organization of caveolin1-1-associated membrane domains.
Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).
- L. Axelsen, M. Stahlhut, +7 authors A. Kjølbye
- Chemistry, MedicineJournal of molecular and cellular cardiology
- 1 June 2006
The results suggest that phosphorylation of Ser297 and Ser368 may be involved in functional gating of Cx43 during ischemia and may be possible downstream targets for rotigaptide signaling.
The Chloride Channel Inhibitor NS3736 Prevents Bone Resorption in Ovariectomized Rats Without Changing Bone Formation
- S. Schaller, K. Henriksen, +17 authors M. Karsdal
- Chemistry, MedicineJournal of bone and mineral research : the…
- 1 July 2004
A chloride channel inhibitor is tested on bone turnover and found that it inhibits bone resorption without affecting bone formation, indicating that chloride channel inhibitors are highly promising for treatment of osteoporosis.
The Antiarrhythmic Peptide Rotigaptide (ZP123) Increases Connexin 43 Protein Expression in Neonatal Rat Ventricular Cardiomyocytes
- M. Stahlhut, J. Petersen, J. Hennan, M. T. Ramirez
- Biology, MedicineCell communication & adhesion
- 1 January 2006
The findings suggest that rotigaptide's effect on Cx43 expression is partly due to increased biosynthesis, and it is suggested that this peptide is a novel antiarrhythmic peptide applicable to protein synthesis.
Strontium Is a Biased Agonist of the Calcium-Sensing Receptor in Rat Medullary Thyroid Carcinoma 6-23 Cells
- Alex R. B. Thomsen, J. Worm, Stine E. Jacobsen, M. Stahlhut, Markus Latta, H. Bräuner‐Osborne
- Chemistry, MedicineJournal of Pharmacology and Experimental…
- 1 December 2012
The results suggest that calcitonin secretion can be affected by CaSR-stimulated signaling bias, which may be used to develop novel drugs for the treatment of secondary hyperparathyroidism.
Ingenol mebutate: induced cell death patterns in normal and cancer epithelial cells.
- M. Stahlhut, M. Bertelsen, +6 authors J. Zibert
- MedicineJournal of drugs in dermatology : JDD
- 1 October 2012
The findings reveal that ingenol mebutate does not mediate cytotoxicity by a simple lytic, necrotic mechanism, but activates distinct processes involving multiple cell organelles in a cell-type and differentiation-dependent manner.
A simple procedure for morphometric analysis of processes and growth cones of neurons in culture using parameters derived from the contour and convex hull of the object 1 More information about the…
- A. Kawa, M. Stahlhut, A. Berezin, E. Bock, V. Berezin
- Medicine, MathematicsJournal of Neuroscience Methods
- 31 January 1998
Morphometric estimation of neuronal processes is currently laborious and time-consuming, since the individual processes (axons and dendrites) have to be traced manually. In order to facilitate the…
Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer.
- Xifu Liang, G. Grue-Sørensen, +6 authors T. Högberg
- Chemistry, MedicineBioorganic & medicinal chemistry letters
- 15 October 2013
A number of derivatives related to ingenol mebutate were prepared by chemical synthesis from ingenol with the purpose of investigating the SAR and potency in assays relating to pro-inflammatory effects, the potential of cell death induction, and the chemical stability.
Amylin(1–8) is Devoid of Anabolic Activity in Bone
- M. Ellegaard, C. Thorkildsen, +6 authors M. Stahlhut
- Chemistry, MedicineCalcified Tissue International
- 3 February 2010
Evaluated effects of amylin(1–8) in ovariectomized rats with established osteopenia, a model for postmenopausal osteoporosis, indicate that this peptide does not show agonist activity onAmylin receptors, does not affect osteoblast proliferation, and is devoid of anabolic activity in bone.