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TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.
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Neurochemical compensation after nigrostriatal bundle injury in an animal model of preclinical parkinsonism.
TLDR
In these studies, damage to the nigrostriatal bundle of the rat was accompanied by apparent increases in the synthesis and release of dopamine from those dopaminergic terminals that remained, and both the activity of the rate-limiting biosynthetic enzyme and the content of the principal DA metabolite were increased in striatum relative to DA levels.
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Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C
TLDR
A new model for gene regulation is proposed in which nuclear FGFR1 acts as a mediator of CRE transactivation by AII, cell depolarization, and PKC.
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Integrative nuclear FGFR1 signaling (INFS) as a part of a universal “feed‐forward‐and‐gate” signaling module that controls cell growth and differentiation
TLDR
It is proposed that FGFR1 is part of a universal “feed‐forward‐and‐gate” signaling module in which classical signaling cascades initiated by specific membrane receptors transmit signals to sequence specific transcription factors (ssTFs), while INFS elicited by the same stimuli feeds the signal forward to the common coactivator, CREB‐binding protein (CBP).
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Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control.
TLDR
The findings support a general mechanism in which gene activation is governed by protein movement and collisions with other proteins and nuclear structures.
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Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain.
TLDR
The results of this nanomedicine approach using ORMOSIL nanoparticles as a nonviral gene delivery platform have a promising future direction for effective therapeutic manipulation of the neural stem/progenitor cells as well as in vivo targeted brain therapy.
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Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1
Studies of induced pluripotent stem cells (iPSCs) from schizophrenia patients and control individuals revealed that the disorder is programmed at the preneuronal stage, involves a common dysregulated…
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Nuclear accumulation of fibroblast growth factor receptors in human glial cells-association with cell proliferation
TLDR
The results suggest that the constitutive nuclear presence of FGFR1 contributes to the increased proliferation of glioma cells while the transient nuclear accumulation ofFGFR1 in normal astrocytes may play a role in the transition to a reactive state.
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Nuclear trafficking of FGFR1: A role for the transmembrane domain
TLDR
The results indicate that an unstable association with cellular membranes is responsible for the release ofFGFR1 into the cytosol and cytosolic FGFR1 constitutes the source of the nuclear receptor, demonstrating that the FG FR1 TM does not function as a NLS.
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Coordinate and differential regulation of phenylethanolamine N-methyltransferase, tyrosine hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary…
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