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Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
TLDR
A comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis, suggests that gene “inventions” along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.
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The Trichoplax genome and the nature of placozoans
TLDR
Despite the apparent cellular and organismal simplicity of Trichoplax, its genome encodes a rich array of transcription factor and signalling pathway genes that are typically associated with diverse cell types and developmental processes in eumetazoans, motivating further searches for cryptic cellular complexity and/or as yet unobserved life history stages.
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The Amphimedon queenslandica genome and the evolution of animal complexity
TLDR
Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes.
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Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals
TLDR
This work identifies small RNAs from animal phyla that diverged before the emergence of the Bilateria, a close relative of the cnidarian Nematostella vectensis (starlet sea anemone), which possesses an extensive repertoire of miRNA genes, two classes of piRNAs and a complement of proteins specific to small-RNA biology comparable to that of humans.
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Anatomy and development of the nervous system of Nematostella vectensis, an anthozoan cnidarian
TLDR
Early neurons and stem cell populations identified with NvMsi, NvELAV, and NvGCM, indicate that neural differentiation occurs throughout the animal and initiates prior to the conclusion of gastrulation.
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A regulatory program for excretory system regeneration in planarians
TLDR
It is determined that planarian and vertebrate excretory cells express homologous proteins involved in reabsorption and waste modification and suggest that metazoan excretary systems are regulated by genetic programs that share a common evolutionary origin.
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Whole-Body Acoel Regeneration Is Controlled by Wnt and Bmp-Admp Signaling
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Early evolution of the LIM homeobox gene family
TLDR
A scenario in which Lhx genes play a homologous role in neural patterning across eumetazoans is proposed, with all six subfamilies already diverged prior to the cnidarian-placozoan-bilaterian last common ancestor.
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Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways.
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Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program
TLDR
This work analyzes the molecular evolution of the proto-oncogene yes-associated protein (Yap)/Yorkie, a key effector of the Hippo signaling pathway that controls organ size in both Drosophila and mammals and reveals a conserved Yap-dependent gene expression signature likely to mediate organ size control throughout bilaterian animals.
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