M. Spiller

Publications40
h-index21
Citations1,552
Highly Influential Citations25
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Relaxometry of brain: Why white matter appears bright in MRI
The remarkable success of magnetic resonance imaging of adult brain relates to the unusually large ratio of the longitudinal relaxation rates 1 / T1 of white and gray matter, ∼2:1 at physiological… Expand
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Relaxation of water protons in the intra‐ and extracellular regions of blood containing Gd(DTPA)
The magnetic field dependence of the longitudinal relaxation rates 1/T1 (NMRD profiles) of blood and plasma from rabbits before and after injection of Gd(DTPA) are reported as a function of magnetic… Expand
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Synthesis and evaluation of a high relaxivity manganese(II)-based MRI contrast agent.
The manganese(II) ion has many favorable properties that lead to its potential use as an MRI contrast agent: high spin number, long electronic relaxation time, labile water exchange. The present work… Expand
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Species Dependence on Plasma Protein Binding and Relaxivity of the Gadolinium-Based MRI Contrast Agent MS-325
Rationale and Objectives:We sought to determine whether there is a species dependence on plasma protein and serum album binding and/or relaxivity of the MR contrast agent MS-325. Methods:Equilibrium… Expand
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Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent.
The design of effective pH responsive MRI contrast agents is a key goal in the development of new diagnostic methods for conditions such as kidney disease and cancer. A key factor determining the… Expand
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Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH.
The pH-sensitive contrast agent, GdDOTA-4AmP (Gd1) has been successfully used to map tissue pH by MRI. Further studies now demonstrate that two distinct chemical forms of the complex can be prepared… Expand
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Relaxometry of Noncalcified Human Meningiomas Correlation with Histology and Solids Content
RATIONALE AND OBJECTIVESResected meningiomas were examined by relaxometry and light microscopy to evaluate the potential of magnetic resonance imaging (MRI) for identifying histologic subtypes and… Expand
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NC100150 injection, a preparation of optimized iron oxide nanoparticles for positive‐contrast MR angiography
A preparation of monocrystalline iron oxide nanoparticles with an oxidized starch coating, currently in clinical trials (NC100150 Injection; CLARISCAN™), was characterized by magnetization… Expand
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Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent.
The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl] diethylenetriaminepentaacetato) (aquo)gadolinium(III)}) is a contrast agent for magnetic… Expand
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Permeability of liposomal membranes to water: Results from the magnetic field dependence of T1 of solvent protons in suspensions of vesicles with entrapped paramagnetic ions
The diffusive permeability to water molecules, Pd, of lipid vesicles with entrapped paramagnetic solute ions can be determined rapidly from analysis of the magnetic field dependence (nuclear magnetic… Expand
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