Foxp3 expression in human cancer cells
- V. Karanikas, M. Speletas, A. Germenis
- Biology, MedicineJournal of Translational Medicine
- 22 April 2008
Evidence is offered that Foxp3 expression, characterizes tumor cells of various tissue origins, and warrants further investigation in the context of tumor immune escape, and under the light of current anti-cancer efforts interfering with Fox p3 expression.
Genetics of Hereditary Angioedema Revisited
- A. Germenis, M. Speletas
- Medicine, BiologyClinical reviews in allergy and immunology
- 26 April 2016
Large scale, in-depth genetic studies are expected not only to answer these emerging questions but also to further elucidate many of the unmet aspects of angioedema pathogenesis.
Regulation of the autophagic machinery in human neutrophils
- I. Mitroulis, I. Kourtzelis, K. Ritis
- Biology, MedicineEuropean Journal of Immunology
- 1 May 2010
Evidence is provided that autophagy is implicated in human neutrophils in both a phagocytosis‐independent (rapamycin, TLR agonists, PMA) and phagcytosis (Escherichia coli)‐dependent initiation manner and a transcriptional level of regulation for the autophagic machinery.
International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency
- H. Farkas, I. Martínez-Saguer, B. Zuraw
- MedicineAllergy. European Journal of Allergy and Clinical…
- 8 September 2016
This work intended to produce consensus recommendations for the diagnosis and management of pediatric patients with C1‐INH‐HAE.
MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever
- S. Giaglis, V. Papadopoulos, K. Ritis
- Medicine, BiologyClinical Genetics
- 1 May 2007
Analysis of the spectrum of MEFV alterations in FMF patients and healthy individuals in Greece revealed that Greeks rely closer to the eastern than western populations of the Mediterranean Basin.
Repeated leftover serosurvey of SARS-CoV-2 IgG antibodies, Greece, March and April 2020
- Zacharoula Bogogiannidou, A. Vontas, C. Hadjichristodoulou
- MedicineEuro surveillance : bulletin Europeen sur les…
- 1 August 2020
These findings confirm low COVID-19 incidence in Greece and possibly the effectiveness of early measures, and confirm the low prevalence in females, older individuals and residents of large urban areas.
Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.
- A. Rosendahl, M. Speletas, K. Leandersson, F. Ivars, P. Sideras
- BiologyInternational Immunology
- 1 December 2003
The functional experiments in vitro suggest that members of the TGF-beta family (TGF- beta or Activin) may play important non-redundant roles during different stages of thymopoiesis.
Hereditary angioedema: molecular and clinical differences among European populations.
- M. Speletas, Á. Szilágyi, A. Germenis
- MedicineJournal of Allergy and Clinical Immunology
- 1 February 2015
Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation
- M. Speletas, N. Argentou, A. Germenis
- Biology, MedicineMediators of Inflammation
- 25 May 2011
Results indicate that, independently of the initial inducer, liver inflammation is correlated with elevated expression of apoptosis mediators and is followed by local Treg accumulation, which was positively correlated with the intensity of inflammation.
Fabry disease due to D313Y and novel GLA mutations
- K. Koulousios, K. Stylianou, A. Germenis
- Medicine, BiologyBMJ Open
- 1 October 2017
It seems that the D313Y mutation is related to a later-onset milder phenotype than the typical phenotype with normal lysoGb3 concentration, which underlines the significance of family member genotyping and newborn screening to avoid misdiagnoses and crucial delays in diagnosis and treatment of the disease.