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Characterization of cry Genes in a Mexican Bacillus thuringiensis Strain Collection
- A. Bravo, Sergio Sarabia, R. Quintero
- Medicine, BiologyApplied and Environmental Microbiology
- 1 December 1998
The results indicate the presence of strains that may harbor potentially novel Cry proteins as well as strains with combinations of less frequently observed cry genes, which could lead to novel bioinsecticidal products.
Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control.
Bacillus thuringiensis: A story of a successful bioinsecticide.
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design.
Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains.
Cadherin‐like receptor binding facilitates proteolytic cleavage of helix α‐1 in domain I and oligomer pre‐pore formation of Bacillus thuringiensis Cry1Ab toxin
Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor.
- C. Perez, L. E. Fernández, A. Bravo
- BiologyProceedings of the National Academy of Sciences…
- 20 December 2005
Evidence is provided that Cyt1Aa functions as a receptor of Cry11Aa, a highly effective pathogenic bacterium that produces a toxin and also its functional receptor, promoting toxin binding to the target membrane and causing toxicity.
Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection.
Activity of Cry1AMod toxins, which are able to form toxin oligomers in the absence of receptors, against different resistant populations, supports the hypothesis that toxin oligomerization is a limiting step in the Cry insecticidal activity.
A GPI-anchored alkaline phosphatase is a functional midgut receptor of Cry11Aa toxin in Aedes aegypti larvae.
- L. E. Fernández, K. Aimanova, S. Gill, A. Bravo, M. Soberón
- BiologyThe Biochemical journal
- 15 February 2006
Results shows that GPI-ALP is an important receptor molecule involved in Cry11Aa interaction with midgut cells and toxicity to Ae.
Engineering Modified Bt Toxins to Counter Insect Resistance
It is suggested that cadherin promotes Bt toxicity by facilitating toxin oligomerization and it is demonstrated that the modified Bt toxins may be useful against pests resistant to standard BT toxins.