Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
- D. Moreira, S. Costa, A. Leite
- Biology, ChemistryJournal of Medicinal Chemistry
- 7 December 2012
One high-efficacy trypanocidal compound was able to be identified, 2-minothiazolidin-4-one 18, which inhibited the activity of cruzain and the proliferation of epimastigotes and was cidal for trypomastigote but was not toxic for splenocytes.
Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae).
- Rosana P. C. Ferraz, Diogo S. Bomfim, D. Bezerra
- Biology, ChemistryPhytomedicine
- 15 May 2013
Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia.
- J. O. Costa, J. Barbosa-Filho, M. Soares
- Biology, MedicineInternational Immunopharmacology
- 1 December 2014
ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.
- L. Dutra, L. Bomfim, D. Bezerra
- ChemistryBioorganic & Medicinal Chemistry Letters
- 1 August 2014
Antiparasitic activities of novel ruthenium/lapachol complexes.
- M. Barbosa, R. CorrĂȘa, A. Batista
- ChemistryJournal of Inorganic Biochemistry
- 1 July 2014
Anti-Trypanosoma cruzi activity of nicotinamide.
- M. Soares, C. V. Silva, W. Azevedo
- BiologyActa Tropica
- 1 May 2012
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.
- C. D. da Rocha, E. Queiroz, J. Wolfender
- Biology, ChemistryJournal of Natural Products
- 28 May 2014
The nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, theâŠ
Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities.
- TĂĄssia L A Dos Santos, R. Queiroz, A. M. Waldschmidt
- BiologyAnais da Academia Brasileira de CiĂȘncias
- 2017
The results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases.
Cytotoxic potential of selected medicinal plants in northeast Brazil
- Thiago B. C. da Silva, C. O. D. Costa, D. Bezerra
- BiologyBMC Complementary and Alternative Medicine
- 8 July 2016
The cytotoxic activity of 18 plants from 16 families that are found in the northeast region of Brazil were investigated to understand the therapeutics potentialities of Brazilian medicinal plants.
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
- A. Rodrigues, L. Bomfim, D. Bezerra
- ChemistryPlanta Medica
- 30 June 2015
The essential oil from the leaves of D. gardneriana presented ÎČ-bisabolene as the major constituent and showed cytotoxic and antitumor potential.
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