Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
One high-efficacy trypanocidal compound was able to be identified, 2-minothiazolidin-4-one 18, which inhibited the activity of cruzain and the proliferation of epimastigotes and was cidal for trypomastigote but was not toxic for splenocytes.
Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae).
Potent anti-inflammatory activity of betulinic acid treatment in a model of lethal endotoxemia.
ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation.
Antiparasitic activities of novel ruthenium/lapachol complexes.
Anti-Trypanosoma cruzi activity of nicotinamide.
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.
The nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, the…
Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities.
- Tássia L A Dos Santos, R. Queiroz, A. M. Waldschmidt
- BiologyAnais da Academia Brasileira de Ciências
The results indicate the therapeutic potential of geopropolis from M. mondury against inflammatory, oxidative, infectious, and neoplastic diseases.
Cytotoxic potential of selected medicinal plants in northeast Brazil
- Thiago B. C. da Silva, C. O. D. Costa, D. Bezerra
- BiologyBMC Complementary and Alternative Medicine
- 8 July 2016
The cytotoxic activity of 18 plants from 16 families that are found in the northeast region of Brazil were investigated to understand the therapeutics potentialities of Brazilian medicinal plants.
Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana.
The essential oil from the leaves of D. gardneriana presented β-bisabolene as the major constituent and showed cytotoxic and antitumor potential.