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A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
STUDY OBJECTIVES To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. DESIGN Subjects were genotyped using polymerase chainExpand
Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia.
OBJECTIVE To investigate the effect of melatonin treatment on sleep, behavior, cognition, and quality of life in children with attention-deficit/hyperactivity disorder (ADHD) and chronic sleep onsetExpand
A single‐nucleotide polymorphism in the 5′‐untranslated region of the hPER2 gene is associated with diurnal preference
The PERIOD2 (PER2) gene is a key component of the molecular mechanism that generates circadian rhythms in mammals. A missense mutation in the human PER2 gene has previously been linked to advancedExpand
Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, theExpand
The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects
Mutations in clock genes are associated with abnormal circadian parameters, including sleep. An association has been reported previously between a polymorphism (3111C), situated in theExpand
Idiopathic Chronic Sleep Onset Insomnia in Attention‐Deficit/Hyperactivity Disorder: A Circadian Rhythm Sleep Disorder
To investigate whether ADHD‐related sleep‐onset insomnia (SOI) is a circadian rhythm disorder, we compared actigraphic sleep estimates, the circadian rest‐activity rhythm, and dim light melatoninExpand
Current role of melatonin in pediatric neurology: clinical recommendations.
BACKGROUND/PURPOSE Melatonin, an indoleamine secreted by the pineal gland, plays a key role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and free radicalExpand
Melatonin in mood disorders
The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the existence of disturbed sleep–wake and core body temperature rhythms, all suggest that dysfunction of theExpand
Delayed sleep phase syndrome: A placebo‐controlled cross‐over study on the effects of melatonin administered five hours before the individual dim light melatonin onset
In a double‐blind placebo‐controlled cross‐over study, 30 patients with Delayed Sleep Phase Syndrome (DSPS) were included, of whom 25 finished the study. Melatonin 5 mg was administered during twoExpand
Long‐term follow‐up of melatonin treatment in children with ADHD and chronic sleep onset insomnia
Abstract:  We conducted this study to assess long‐term melatonin treatment course, effectiveness and safety in children with attention‐deficit/hyperactivity disorder (ADHD) and chronic sleep onsetExpand