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The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of…
It is suggested that nocturnal surge on D-2, PROLACTin is the major Luteotropic stimulus which transforms and estrous cycle into pseudopregnancy by prolonging progesterone secretion from the corpus luteum.
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates.
- C. McCurdy, J. Bishop, K. Grove
- Medicine, BiologyThe Journal of clinical investigation
- 2 February 2009
It is found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs), and exposure to this may increase the risk of pediatric NAFLD.
c-Fos and Related Immediate Early Gene Products as Markers of Activity in Neuroendocrine Systems
Both c-Fos and c-Jun are expressed in neuroendocrine neurons in response to a number of stimuli, setting the stage for potential regulatory drive to genes containing AP-1 binding sites.
Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone.
- W. S. Lee, M. Smith, G. Hoffman
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 July 1990
Examination of luteinizing hormone-releasing hormone (LHRH) neurons during proestrus provides direct evidence that stimulation of LHRH neurons during Proestrus takes place at the L HRH cell bodies, and identifies the specific population of LhrH neurons which are activated.
Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat.
- M. Smith
- 1 September 1993
Given that lactation is an estrogen-deficient state, the increase in NPY neuronal activity, as indicated by increased gene expression in the caudal portion of the ARC and increased content in the ME, could play an inhibitory role in the regulation of GnRH secretion.
Chronic Consumption of a High-Fat Diet during Pregnancy Causes Perturbations in the Serotonergic System and Increased Anxiety-Like Behavior in Nonhuman Primate Offspring
It is found that maternal high-fat diet (HFD) consumption during gestation caused perturbations in the central serotonergic system of fetal offspring, and female infants from HFD-fed mothers exhibited increased anxiety in response to threatening novel objects.
Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.
AGRP is most likely to be involved in modulating a conserved subset of the physiological functions of central melanocortin peptides, which are likely to include the central control of energy homeostasis.
Integration of the regulation of reproductive function and energy balance: lactation as a model
Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation.
The high degree of colocalization of AGRP and NPY, coupled with previous reports from the laboratory demonstrating increased NPY expression in the ARH in response to suckling, suggests that A GRP andNPY are coordinately regulated and may be involved in the increase in food intake during lactation.
Regulation of food intake and gonadotropin-releasing hormone/luteinizing hormone during lactation: role of insulin and leptin.
Results suggest that the negative energy balance of lactation is not required for the hyperphagic drive, although it is involved in the orexigenic changes in the ARH, which is most likely sustained by the induction of NPY in the DMH.