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Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28*
TLDR
The data suggest that a high level of constitutive activity might be a more general characteristic of viral G protein-coupled receptors and that human cytomegalovirus might exploit this G Protein-Coupled receptor property to modulate the homeostasis of infected cells via the early gene product US28. Expand
Molecular pharmacological aspects of histamine receptors.
TLDR
The description of pharmacological tools for the H1, H2 and H3 receptor, including the recent cloning of the receptor genes, and their respective signal transduction mechanisms are described. Expand
Identification of rat H3 receptor isoforms with different brain expression and signaling properties.
TLDR
The identification of these new H3 receptor isoforms and their specific signaling properties adds a new level of complexity to the understanding of the role of histamine, and the H3 receptors in brain function. Expand
Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis
TLDR
The studies reveal that expression of US28 induces a proangiogenic and transformed phenotype by up-regulating the expression of vascular endothelial growth factor and enhancing cell growth and cell cycle progression, indicating the importance of constitutive receptor activity in the early onset of tumor development. Expand
HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis
TLDR
It is proposed that US28 induces proliferation in HCMV-infected tumors by establishing a positive feedback loop through activation of the IL-6–STAT3 signaling axis throughactivation of the JAK1-STAT3 axis. Expand
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation.
TLDR
PKA treatment of recombinant AC6 in insect cell membranes results in a selective loss of stimulation by high (>10 nM) concentrations of Galphas, suggesting a mechanism of how isoform selective regulatory diversity can be obtained within conserved regions involved in signal communication. Expand
The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2.
TLDR
The development of HCMV-related proliferative diseases may partially be ascribed to the ability of US28 to activate COX-2, a key mediator of inflammatory diseases and major determinant in several forms of cancer. Expand
Pharmacological modulation of chemokine receptor function
TLDR
An overview of the evidence supporting modulation of this intriguing receptor family by a range of ligands, including small molecules, peptides and antibodies is given. Expand
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
TLDR
The displayed inverse agonism of H2 antagonists appears to be a mechanistic basis for the observed H2 antagonist-induced H2 receptor upregulation in transfected CHO cells, which shed new light on the pharmacological classification of the H 2 antagonists and may offer a plausible explanation for the observation of tolerance after prolonged clinical use. Expand
Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling.
TLDR
It is shown that the histamine H(1) receptor, which is also an important player in allergic and inflammatory conditions, activates NF-kappa B in both a constitutive and agonist-dependent manner. Expand
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