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  • Influence
Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening
TLDR
A side-by-side comparison of this new fluorescence assay and a standard radioisotopic method suggest that it may be an ideal method for high-throughput antimalarial drug screening. Expand
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)
TLDR
It is concluded that N-acetylcysteine treatment should be started within eight hours of an acetaminophen overdose, but that treatment is still indicated at least as late as 24 hours after ingestion, and it may be superior when treatment is delayed. Expand
Discovery of dual function acridones as a new antimalarial chemotype
TLDR
This innovative acridone design merges intrinsic potency and resistance-counteracting functions in one molecule, and represents a new strategy to expand, enhance and sustain effective antimalarial drug combinations. Expand
A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.
TLDR
A preliminary study in mice demonstrated oral efficacy against P. chabaudi and the absence of obvious toxicity, and the RCQ approach appears to be feasible. Expand
Evaluation and lead optimization of anti-malarial acridones.
TLDR
It is proposed that the haloalkoxyacridones exert their anti-malarial effects through inhibition of the Plasmodium cytochrome bc(1) complex. Expand
Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol.
TLDR
This 48-hour IV N-acetylcysteine treatment protocol is safe and effective antidotal therapy for acetaminophen overdose and is equal to 72-hour oral and 20-hour intravenous treatment protocols when started early and superior to the 20- hour IV regimen when treatment is delayed. Expand
Osmol gaps revisited: normal values and limitations.
TLDR
The osmol gap in patients whose serum ethanol concentrations are known, to reevaluate several accepted equations for calculating osmolarity, and to apply the results to the theoretical clinical scenario of a toxic alcohol ingestion is defined. Expand
Antimalarial activity of natural and synthetic prodiginines.
TLDR
The in vitro antimalarial activity of four natural and three sets of synthetic prodiginines against Plasmodium falciparum was described and each analogue reduced parasitemia by more than 90% after 25 (mg/kg)/day dosing and in some cases provided a cure. Expand
A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.
TLDR
This transformation defies expected molecular-based concepts of drug resistance, has important implications for the study of cyt bc(1) as an antimalarial drug target, and may offer a glimpse into the evolutionary future of Plasmodium. Expand
Design, Synthesis, and Evaluation of 10-N-Substituted Acridones as Novel Chemosensitizers in Plasmodium falciparum
TLDR
The combined results indicate that 10-N-substituted acridones present novel pharmacophores for the development of chemosensitizers against P. falciparum. Expand
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